Liquidambar orientalisMill. gum extract induces autophagy via PI3K/Akt/mTOR signaling pathway in prostate cancer cells

Simple item page
dc.contributor.authorAtmaca, H
dc.contributor.authorPulat, CC
dc.contributor.authorCittan, M
dc.date.accessioned2024-07-18T11:53:51Z
dc.date.available2024-07-18T11:53:51Z
dc.description.abstractLiquidambar orientalisMill . (LOM), is an endemic species having a local distribution in the southwestern coastal district of Turkey. Styrax liquidus gum (SLG), is a gum-like resinous which exudates in response to injury of the trunk of LOM. The aim of the study was to investigate the cytotoxic effects and the molecular mechanisms of the ethanolic SLG extract in human prostate cancer cells. GC-MS analysis was performed to identify the volatile compound composition. Cytotoxicity was determined by XTT analysis. Apoptosis and necrosis were evaluated via ELISA assay. Autophagic cell death was detected via monodansylcadaverine (MDC) staining and by measuring the levels of LC3I and LC3II. The protein levels of p-PI3K, p-Akt and p-mTOR were evaluated by western blot analysis. In the present study, it is shown that the SLG extract containing a considerable amount of ravidomycin derivate induced autophagic cell death in prostate cancer cells via inhibiting the PI3K/Akt/mTOR pathway.
dc.identifier.issn0960-3123
dc.identifier.other1369-1619
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/5932
dc.language.isoEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectTRADITIONAL MEDICINE
dc.subjectFOLK MEDICINE
dc.subjectAPOPTOSIS
dc.subjectINDUCTION
dc.subjectTURKEY
dc.subjectDEATH
dc.subjectOILS
dc.titleLiquidambar orientalisMill. gum extract induces autophagy via PI3K/Akt/mTOR signaling pathway in prostate cancer cells
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu