Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines
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Date
2019
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Abstract
Cancer is a common cause of death worldwide. Approximately 80% of cancer patients use complementary or alternative medicines for treatment. Caffeic acid phenethyl ester (CAPE), the main active component of propolis, exhibits cytotoxic, antiproliferative and anti-cancer effects. Despite its anticancer effects CAPE exhibits no known harmful effects toward normal cells. We investigated the effects of CAPE on angiogenesis, apoptosis and oxidative stress using MDA MB-231, N2a and COLO 320 cell lines and CAPE treatments at 24 and 48 h. A two dimensional cell culture system was used and the findings were evaluated by an indirect immunohistochemical method and H-scores were calculated. CAPE was effective for all three cancer cell lines. After 24 and 48 h, we found a significant decrease in live cells and increased stress in the cells based on e-NOS and i-NOS levels. © 2019, © 2019 The Biological Stain Commission.
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Angiogenesis Inducing Agents , Antineoplastic Agents , Apoptosis , Caffeic Acids , Cell Line, Tumor , Cell Proliferation , Cell Survival , Humans , Neovascularization, Pathologic , Oxidative Stress , Phenylethyl Alcohol , Propolis , angiogenic factor , antineoplastic agent , caffeic acid derivative , caffeic acid phenethyl ester , phenethyl alcohol , propolis , apoptosis , cell proliferation , cell survival , drug effect , human , metabolism , neovascularization (pathology) , oxidative stress , tumor cell line