Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines

Simple item page
dc.contributor.authorFırat F.
dc.contributor.authorÖzgül M.
dc.contributor.authorTürköz Uluer E.
dc.contributor.authorInan S.
dc.date.accessioned2024-07-22T08:08:14Z
dc.date.available2024-07-22T08:08:14Z
dc.date.issued2019
dc.description.abstractCancer is a common cause of death worldwide. Approximately 80% of cancer patients use complementary or alternative medicines for treatment. Caffeic acid phenethyl ester (CAPE), the main active component of propolis, exhibits cytotoxic, antiproliferative and anti-cancer effects. Despite its anticancer effects CAPE exhibits no known harmful effects toward normal cells. We investigated the effects of CAPE on angiogenesis, apoptosis and oxidative stress using MDA MB-231, N2a and COLO 320 cell lines and CAPE treatments at 24 and 48 h. A two dimensional cell culture system was used and the findings were evaluated by an indirect immunohistochemical method and H-scores were calculated. CAPE was effective for all three cancer cell lines. After 24 and 48 h, we found a significant decrease in live cells and increased stress in the cells based on e-NOS and i-NOS levels. © 2019, © 2019 The Biological Stain Commission.
dc.identifier.DOI-ID10.1080/10520295.2019.1589574
dc.identifier.issn10520295
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/14313
dc.language.isoEnglish
dc.publisherTaylor and Francis Ltd
dc.subjectAngiogenesis Inducing Agents
dc.subjectAntineoplastic Agents
dc.subjectApoptosis
dc.subjectCaffeic Acids
dc.subjectCell Line, Tumor
dc.subjectCell Proliferation
dc.subjectCell Survival
dc.subjectHumans
dc.subjectNeovascularization, Pathologic
dc.subjectOxidative Stress
dc.subjectPhenylethyl Alcohol
dc.subjectPropolis
dc.subjectangiogenic factor
dc.subjectantineoplastic agent
dc.subjectcaffeic acid derivative
dc.subjectcaffeic acid phenethyl ester
dc.subjectphenethyl alcohol
dc.subjectpropolis
dc.subjectapoptosis
dc.subjectcell proliferation
dc.subjectcell survival
dc.subjectdrug effect
dc.subjecthuman
dc.subjectmetabolism
dc.subjectneovascularization (pathology)
dc.subjectoxidative stress
dc.subjecttumor cell line
dc.titleEffects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines
dc.typeArticle

Files

Collections

Scopus Koleksiyonu