The increase of neuropathic symptoms in diabetic patients is related with osteopenia
| dc.contributor.author | Börekci E. | |
| dc.contributor.author | Kara A. | |
| dc.contributor.author | Kılıç M. | |
| dc.contributor.author | Tanık N. | |
| dc.contributor.author | Ozan Z.T. | |
| dc.contributor.author | Yıldırım T. | |
| dc.contributor.author | Aral Y. | |
| dc.date.accessioned | 2025-04-10T11:05:32Z | |
| dc.date.available | 2025-04-10T11:05:32Z | |
| dc.date.issued | 2021 | |
| dc.description.abstract | Purpose: To investigate the relationship between the intensity of neuropathic pain and the severity of osteopenia in type 2 diabetic patients with painful diabetic peripheral neuropathy (painful DPN). Methods: In 220 patients with type 2 diabetes included in the screening, the presence of neuropathic pain was evaluated using the Douleur Neuropathique 4 Questions (DN4) scoring system. One hundred forty-five patients with painful DPN were identified and included in the study. Socio-demographic and laboratory evaluations were made and bone mineral density (BMD) of these patients was evaluated by the dual-energy x-ray absorptiometry (DEXA) method. Results: There was a significant correlation between the neuropathic pain score and the total T scores of the lumbar spine and femur in patients with painful DPN. According to the regression analysis (standard coefficients), the DN4 score (0.498); the level of vitamin D (− 0.246) and the female sex (0.236) for the lumbar spine region; age (0.387); DN4 score (0.261); and vitamin D level (− 0.155) for the femur region were independently influencing factors on the development of osteoporosis. When osteoporosis (T score ≤ − 2.5) of the lumbar spine was analyzed by binary logistic regression, the risk of osteoporosis in women was 4.4 times higher, and the risk increased with increasing DN4 score. Conclusion: The increase of neuropathic symptoms in patients with DPN is an effective and important factor in the development of diabetic osteopenia. © 2020, Fondazione Società Italiana di Neurologia. | |
| dc.identifier.DOI-ID | 10.1007/s10072-020-04915-3 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/46083 | |
| dc.publisher | Springer-Verlag Italia s.r.l. | |
| dc.title | The increase of neuropathic symptoms in diabetic patients is related with osteopenia | |
| dc.type | Article |