Radiolabeling of new generation magnetic poly(HEMA-MAPA) nanoparticles with 131I and preliminary investigation of its radiopharmaceutical potential using albino Wistar rats

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dc.contributor.authorAvcibasi, U
dc.contributor.authorDemiroglu, H
dc.contributor.authorEdiz, M
dc.contributor.authorAkalin, HA
dc.contributor.authorÖzçaliskan, E
dc.contributor.authorSenay, H
dc.contributor.authorTürkcan, C
dc.contributor.authorÖzcan, Y
dc.contributor.authorAkgöl, S
dc.contributor.authorAvcibasi, N
dc.date.accessioned2024-07-18T12:01:28Z
dc.date.available2024-07-18T12:01:28Z
dc.description.abstractIn this study, N-methacryloyl-l-phenylalanine (MAPA) containing poly(2-hydroxyethylmethacrylate) (HEMA)-based magnetic poly(HEMA-MAPA) nanobeads [mag-poly(HEMA-MAPA)] were radiolabeled with I-131 [I-131-mag-poly(HEMA-MAPA)], and the radiopharmaceutical potential of I-131-mag-poly(HEMA-MAPA) was investigated. Quality control studies were carried out by radiochromatographic method to be sure that I-131 binded to mag-poly(HEMA-MAPA) efficiently. In this sense, binding yield of I-131-mag-poly(HEMA-MAPA) was found to be about 95-100%. In addition to this, optimum radiodination conditions for I-131-mag-poly(HEMA-MAPA) were determined by thin-layer radiochromatography studies. In addition to thin-layer radiochromatography studies, lipophilicity (partition coefficient) and stability studies for I-131-mag-poly(HEMA-MAPA) were realized. It was determined that lipophilicities of mag-poly(HEMA-MAPA) and I-131-mag-poly(HEMA-MAPA) were 0.12 +/- 0.01 and 1.79 +/- 0.76 according to ACD/logP algorithm program, respectively. Stability of the radiolabeled compound was investigated in time intervals given as 0, 30, 60, 180, and 1440min. It was found that I-131-mag-poly(HEMA-MAPA) existed as a stable complex in rat serum within 60min. After that, biodistribution and scintigraphy studies were carried out by using albino Wistar rats. It was determined that the most important I-131 activity uptake was observed in the breast, the ovary, and the pancreas. Scintigraphy studies well supported biodistribution results. Copyright (c) 2013 John Wiley & Sons, Ltd.
dc.identifier.issn0362-4803
dc.identifier.other1099-1344
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8451
dc.language.isoEnglish
dc.publisherWILEY
dc.subject2-HYDROXYETHYL METHACRYLATE
dc.subjectHEMA
dc.subjectRADIOIODINATION
dc.subjectHYDROGELS
dc.subjectBLEOMYCIN
dc.subjectLIPASE
dc.titleRadiolabeling of new generation magnetic poly(HEMA-MAPA) nanoparticles with 131I and preliminary investigation of its radiopharmaceutical potential using albino Wistar rats
dc.typeArticle

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