Effect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study

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dc.contributor.authorYilmaz, S
dc.contributor.authorDemirci, NY
dc.contributor.authorMetintas, S
dc.contributor.authorZamani, A
dc.contributor.authorKaradag, M
dc.contributor.authorGuçlu, OA
dc.contributor.authorKabalak, PA
dc.contributor.authorYilmaz, U
dc.contributor.authorAk, G
dc.contributor.authorKizilgoz, D
dc.contributor.authorOzturk, A
dc.contributor.authorYilmaz, U
dc.contributor.authorBatum, O
dc.contributor.authorKavas, M
dc.contributor.authorSerifoglu, I
dc.contributor.authorUnsal, M
dc.contributor.authorKomurcuoglu, BE
dc.contributor.authorCengiz, TI
dc.contributor.authorUlubay, G
dc.contributor.authorOzdemirel, TS
dc.contributor.authorOzyurek, BA
dc.contributor.authorKavurgaci, S
dc.contributor.authorAlizoroglu, D
dc.contributor.authorCelik, P
dc.contributor.authorErdogan, Y
dc.contributor.authorIn, E
dc.contributor.authorAksoy, A
dc.contributor.authorAltin, S
dc.contributor.authorGunluoglu, G
dc.contributor.authorMetintas, M
dc.date.accessioned2024-07-18T12:07:47Z
dc.date.available2024-07-18T12:07:47Z
dc.description.abstractObjective: The aim of this study is to investigate the effect of asbestos exposure on cancer-driver mutations. Methods: Between January 2014 and September 2018, epidermal growth factor receptor (EGFR), anaplastic lymphoma receptor tyrosine kinase (ALK), and c-ros oncogene 1 receptor tyrosine kinase gene (ROS1) alterations, demographic characteristics, asbestos exposure, and asbestos-related radiological findings of 1904 patients with lung adenocarcinoma were recorded. Results: The frequencies of EGFR mutations, ALK, and ROS1 rearrangements were 14.5%, 3.7%, and 0.9%, respectively. The rates of EGFR mutations and ALK rearrangements were more frequent in asbestos exposed non-smokers (48.7% and 9%, respectively). EGFR mutation rate was correlated to female gender and not-smoking, ALK rearrangement rate was correlated to younger age, not-smoking, and a history of asbestos exposure. Conclusions: The higher rate of ALK rearrangements in asbestos-exposed lung adenocarcinoma cases shows that asbestos exposure may most likely cause genetic alterations that drive pulmonary adenocarcinogenesis.
dc.identifier.issn1076-2752
dc.identifier.other1536-5948
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10640
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectANAPLASTIC LYMPHOMA KINASE
dc.subjectFACTOR RECEPTOR-MUTATIONS
dc.subjectTARGETED THERAPY
dc.subjectCANCER
dc.subjectASSOCIATION
dc.subjectSMOKING
dc.subjectCLASSIFICATION
dc.subjectEPIDEMIOLOGY
dc.subjectEXPRESSION
dc.subjectSOCIETY
dc.titleEffect of Asbestos Exposure on the Frequency of EGFR Mutations and ALK/ROS1 Rearrangements in Patients With Lung Adenocarcinoma A Multicentric Study
dc.typeArticle

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