Statin treatment reduces oxidative stress-associated apoptosis of sciatic nerve in diabetes mellitus
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Date
2011
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Abstract
Statins are lipid-lowering drugs that are widely used for treating hyperlipidemia, especially in diabetic patients. The aim of our study was to explore the effects of atorvastatin on oxidative stress and apoptosis in the sciatic nerve due to hyperglycemia. Diabetes was induced by streptozotocin. Atorvastatin was given orally for two weeks beginning from the sixth week. Microscopic examination of sciatic nerve revealed that normal tissue organization was disrupted in streptozotocin induced diabetic rats. Treatment with Atorvastatin reduced the histological damage and protected the morphological integrity of the sciatic nerve in streptozotocin induced diabetes. Increased expressions of transforming growth factor beta-1, endothelial nitric oxide synthase and TUNEL in sciatic nerve from streptozotocin induced diabetes were reduced by Atorvastatin. Atorvastatin could improve the effects of oxidative stress and apoptosis on the sciatic nerve due to diabetes. © 2011 The Biological Stain Commission.
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Animals , Apoptosis , Diabetes Mellitus, Experimental , Diabetic Neuropathies , Heptanoic Acids , Hydroxymethylglutaryl-CoA Reductase Inhibitors , Male , Nitric Oxide Synthase , Oxidative Stress , Pyrroles , Rats , Rats, Wistar , Sciatic Nerve , Streptozocin , Transforming Growth Factor beta1 , Rattus , atorvastatin , heptanoic acid derivative , hydroxymethylglutaryl coenzyme A reductase inhibitor , nitric oxide synthase , pyrrole derivative , streptozocin , transforming growth factor beta1 , animal , apoptosis , article , chemically induced disorder , diabetic neuropathy , drug effect , experimental diabetes mellitus , male , metabolism , oxidative stress , pathology , rat , sciatic nerve , Wistar rat