Statin treatment reduces oxidative stress-associated apoptosis of sciatic nerve in diabetes mellitus

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dc.contributor.authorGrpinar T.
dc.contributor.authorEkerbiçer N.
dc.contributor.authorHarzadin N.U.
dc.contributor.authorBarut T.
dc.contributor.authorTarakçi F.
dc.contributor.authorTuglu M.I.
dc.date.accessioned2024-07-22T08:19:55Z
dc.date.available2024-07-22T08:19:55Z
dc.date.issued2011
dc.description.abstractStatins are lipid-lowering drugs that are widely used for treating hyperlipidemia, especially in diabetic patients. The aim of our study was to explore the effects of atorvastatin on oxidative stress and apoptosis in the sciatic nerve due to hyperglycemia. Diabetes was induced by streptozotocin. Atorvastatin was given orally for two weeks beginning from the sixth week. Microscopic examination of sciatic nerve revealed that normal tissue organization was disrupted in streptozotocin induced diabetic rats. Treatment with Atorvastatin reduced the histological damage and protected the morphological integrity of the sciatic nerve in streptozotocin induced diabetes. Increased expressions of transforming growth factor beta-1, endothelial nitric oxide synthase and TUNEL in sciatic nerve from streptozotocin induced diabetes were reduced by Atorvastatin. Atorvastatin could improve the effects of oxidative stress and apoptosis on the sciatic nerve due to diabetes. © 2011 The Biological Stain Commission.
dc.identifier.DOI-ID10.3109/10520295.2010.506159
dc.identifier.issn14737760
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/17905
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectApoptosis
dc.subjectDiabetes Mellitus, Experimental
dc.subjectDiabetic Neuropathies
dc.subjectHeptanoic Acids
dc.subjectHydroxymethylglutaryl-CoA Reductase Inhibitors
dc.subjectMale
dc.subjectNitric Oxide Synthase
dc.subjectOxidative Stress
dc.subjectPyrroles
dc.subjectRats
dc.subjectRats, Wistar
dc.subjectSciatic Nerve
dc.subjectStreptozocin
dc.subjectTransforming Growth Factor beta1
dc.subjectRattus
dc.subjectatorvastatin
dc.subjectheptanoic acid derivative
dc.subjecthydroxymethylglutaryl coenzyme A reductase inhibitor
dc.subjectnitric oxide synthase
dc.subjectpyrrole derivative
dc.subjectstreptozocin
dc.subjecttransforming growth factor beta1
dc.subjectanimal
dc.subjectapoptosis
dc.subjectarticle
dc.subjectchemically induced disorder
dc.subjectdiabetic neuropathy
dc.subjectdrug effect
dc.subjectexperimental diabetes mellitus
dc.subjectmale
dc.subjectmetabolism
dc.subjectoxidative stress
dc.subjectpathology
dc.subjectrat
dc.subjectsciatic nerve
dc.subjectWistar rat
dc.titleStatin treatment reduces oxidative stress-associated apoptosis of sciatic nerve in diabetes mellitus
dc.typeArticle

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