Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum
| dc.contributor.author | Kirkan B. | |
| dc.contributor.author | Sarikurkcu C. | |
| dc.contributor.author | Ozer M.S. | |
| dc.contributor.author | Cengiz M. | |
| dc.contributor.author | Atılgan N. | |
| dc.contributor.author | Ceylan O. | |
| dc.contributor.author | Tepe B. | |
| dc.date.accessioned | 2025-04-10T11:07:42Z | |
| dc.date.available | 2025-04-10T11:07:42Z | |
| dc.date.issued | 2018 | |
| dc.description.abstract | This study focused on phytochemical characterization and biological evaluation, both antioxidant and enzymatic inhibition, of ethyl acetate (OTT-EtOAc), methanol (OTT-MeOH), and water (OTT-W) extracts from Onosma tauricum var. tauricum aerial parts. The OTT-W extract was found to be the richest one in terms of its phenolic and flavonoid contents. Amounts of the phenolic and flavonoid compounds were determined as 40.88 μmol GAEs/g and 7.40 μmol REs/g dry plant (dp), respectively. The OTT-MeOH and OTT-W extracts were also found to contain significant amounts of chlorogenic acid, rosmarinic acid, p-hydroxybenzoic acid, caffeic acid, rutin, p-coumaric acid, trans-cinnamic acid, luteolin, and apigenin. The OTT-W extract showed remarkable antioxidant activity in phosphomolybdenum, ferrous ion chelating, reducing power, and radical scavenging assays. The OTT-MeOH extract exhibited inhibitory activity on acetylcholinesterase (AChE) (54.62 μmol GALAEs/g dp), while the extracts remained almost inactive on butyrylcholinesterase (BChE). The OTT-W extract also exhibited inhibitory activity on tyrosinase (90.66 μmol KAEs/g dp) and α-glucosidase (2258.87 μmol ACEs/g dp). The results suggest that especially the OTT-MeOH and OTT-W extracts can be used as a source of alternative natural products in the treatment of diseases caused by the enzymes evaluated here. © 2018 Elsevier B.V. | |
| dc.identifier.DOI-ID | 10.1016/j.indcrop.2018.09.043 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/47547 | |
| dc.publisher | Elsevier B.V. | |
| dc.title | Phenolic profile, antioxidant and enzyme inhibitory potential of Onosma tauricum var. tauricum | |
| dc.type | Article |