Effects of oxidative stress and apoptosis on vascularity and viability of perforator flaps

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dc.contributor.authorBali, U
dc.contributor.authorAydemir, I
dc.contributor.authorKeçeci, Y
dc.contributor.authorYoleri, L
dc.contributor.authorTuglu, MI
dc.date.accessioned2024-07-18T11:54:06Z
dc.date.available2024-07-18T11:54:06Z
dc.description.abstractWe investigated lateral thoracic and posterior thigh perforator flaps for viability, vascularization, perfusion and apoptosis in a rat model. Wistar albino rats were divided into six groups: lateral thoracic artery perforator flap (LTPF) sham, 3 x 2 cm(2) LTPF, 3 x 6 cm(2) LTPF, posterior thigh perforator flap (PTPF) sham, 3 x 2 cm(2) PTPF, and 3 x 6 cm(2) PTPF. Flap viability was determined on postoperative days 1 and 7. On day 7, flaps were photographed and their viability was measured using two-dimensional planimeter paper. Tissue samples were harvested for examination by histology and immunohistochemistry. Viability differences were statistically significant. Epithelial thickness, vascularity and number of fibroblasts were reduced in the 3 x 6 cm(2) groups. Neovascularization and apoptosis based on molecular tests were not significantly different among groups. Flap size and location are important factors for closure of surgical or traumatic defects. We suggest that for clinical application, wound complications will occur less frequently with perforators that nourish large areas of flaps.
dc.identifier.issn1052-0295
dc.identifier.other1473-7760
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/6111
dc.language.isoEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectENDOTHELIAL GROWTH-FACTOR
dc.subjectSKIN FLAPS
dc.subjectSURVIVAL
dc.subjectANGIOGENESIS
dc.subjectINHIBITION
dc.subjectEXPRESSION
dc.subjectCELLS
dc.titleEffects of oxidative stress and apoptosis on vascularity and viability of perforator flaps
dc.typeArticle

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