Synthesis and Characterization of Piano-Stool Ruthenium(II)-Arene Complexes of Isatin Schiff Bases: Cytotoxicity and DNA Intercalation

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dc.contributor.authorKarabıyık H.
dc.contributor.authorKaraer Tunçay A.
dc.contributor.authorIlhan S.
dc.contributor.authorAtmaca H.
dc.contributor.authorTürkmen H.
dc.date.accessioned2025-04-10T11:02:23Z
dc.date.available2025-04-10T11:02:23Z
dc.date.issued2024
dc.description.abstractA series of aryl-isatin Schiff base derivatives (3a-d) and their piano-stool ruthenium complexes (4a-d) were synthesized and characterized via 1H and 13C NMR and Fourier transform infrared (FTIR) spectroscopy. In addition, the purity of all of the compounds (3a-c and 4a-d) was determined via elemental analysis. Complex 4d was analyzed using X-ray crystallography. An in vitro antiproliferative study of the compounds (3a-c and 4a-d) against human hepatocellular carcinoma (HEPG2), human breast cancer (MCF-7), human prostate cancer (PC-3), and human embryonic kidney (HEK-293) cells exhibited their considerable antiproliferative activity. 4d exhibited effective cytotoxicity against HEPG2 and MCF-7. It displayed higher cytotoxicity than the reference metallo-drug cisplatin. Moreover, the stability of 4d was studied via 1H NMR spectroscopy, and the binding model between 4d and DNA was investigated via ultraviolet-visible spectroscopy. The lipophilicity of the synthesized complexes was determined using an extraction method. © 2024 The Authors. Published by American Chemical Society
dc.identifier.DOI-ID10.1021/acsomega.3c10265
dc.identifier.urihttp://hdl.handle.net/20.500.14701/44001
dc.publisherAmerican Chemical Society
dc.titleSynthesis and Characterization of Piano-Stool Ruthenium(II)-Arene Complexes of Isatin Schiff Bases: Cytotoxicity and DNA Intercalation
dc.typeArticle

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