Successful use of inhaled steroids for the management of radiation pneumonitis in an infant: Case repot; [Radyasyon pnömonisinin tedavisinde i̇nhale steroidlerin bir süt çocuǧunda başarı ile kullanımı]
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Date
2010
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Abstract
Radiation pneumonitis and subsequent pulmonary fibrosis are among the serious complications of thoracic irradiation and can have severe implications on patients' quality of life. Systemic corticosteroids are commonly used agents to treat radiation pneumonitis. However, the potential adverse effects of systemic corticosteroids, particularly in growing children, are consid-erable. An infant with lung metastatic Ewing sarcoma developed severe radiation pneumonitis following chemoradiotherapy. Systemic prednisolone was started first. However, due to the prolonged need for corticosteroid therapy, inhaled budesonide was administered with reduced systemic corticosteroid dose in an attempt to avoid the adverse effects of systemic corticosteroid treatment. The treatment was then continued exclusively with budesonide with a good clinical response. To our knowledge, this is the first pediatric case reported to benefit from inhaled steroids for severe radiation pneumonitis. This response suggested that inhaled steroids might serve as a adjunct or even an alternative to systemic corticosteroids in radiation pneumonitis. © 2010 by Türkiye Klinikleri.
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antibiotic agent , budesonide , carboplatin , cyclophosphamide , doxorubicin , ifosfamide , prednisolone , vincristine , anamnesis , article , cancer radiotherapy , case report , child , computer assisted tomography , disease control , drug administration route , drug dose increase , drug dose reduction , drug efficacy , drug intermittent therapy , Ewing sarcoma , human , male , oxygen therapy , preschool child , radiation dose , radiation pneumonia , steroid therapy , systemic therapy , thorax radiography , treatment duration