A multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression

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dc.contributor.authorAltinbas, K
dc.contributor.authorOzerdem, A
dc.contributor.authorPrieto, ML
dc.contributor.authorFuentes, ME
dc.contributor.authorYalin, N
dc.contributor.authorErsoy, Z
dc.contributor.authorAydemir, O
dc.contributor.authorQuiroz, D
dc.contributor.authorOztekin, S
dc.contributor.authorGeske, JR
dc.contributor.authorFeeder, SE
dc.contributor.authorAngst, J
dc.contributor.authorFrye, MA
dc.date.accessioned2024-07-18T12:07:34Z
dc.date.available2024-07-18T12:07:34Z
dc.description.abstractBackground: Mixed depression is a common, dimensional phenomenon that is increasingly recognized in unipolar and bipolar disorders. We piloted a modified version of the Hypomania Checklist (mHCL-32) to assess the prevalence and clinical correlates of concurrent manic (hypo) symptoms in depressed patients. Methods: The mHCL-32, Young Mania Rating Scale (YMRS) and Hamilton Rating Scale for Depression (IAMD-24) were utilized in the assessment of unipolar (UP=61) and bipolar (BP=44) patients with an index major depressive episode confirmed by the Structured Clinical Interview for DSM-IV (SCID). Differential mHLC-32 item endorsement was compared between UP and BR Correlation analyses assessed the association of symptom dimensions measured by mHCL-32, YMRS and HAMD-24. Results: There was no significant difference between mood groups in the mean rnHCL-32 and YMRS scores. Individual mHLC-32 items of increased libido, quarrels, and caffeine intake were endorsed more in BP vs. UP patients. The mHCL-32 active elevated subscale score was positively correlated with the YMRS in BP patients and negatively correlated with HAMD-24 in UP patients. Conversely, the mHCL-32 irritable risk taking subscale score was positively correlated with HAMD-24 in BP and with YMRS in UP patients. Limitations: Small sample size and cross-sectional design. Conclusion: Modifying the HCL to screen for (hypo) manic symptoms in major depression may have utility in identifying mixed symptoms in both bipolar vs. unipolar depression. Further research is encouraged to quantify mixed symptoms with standardized assessments. (C) 2013 Published by Elsevier B.V.
dc.identifier.issn0165-0327
dc.identifier.other1573-2517
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10511
dc.language.isoEnglish
dc.publisherELSEVIER SCIENCE BV
dc.subjectMOOD DISORDER QUESTIONNAIRE
dc.subjectBIPOLAR DISORDERS
dc.subjectMANIC SYMPTOMS
dc.subjectRATING-SCALE
dc.subjectUNIPOLAR
dc.subjectVALIDITY
dc.subjectSTATES
dc.subjectPREVALENCE
dc.subjectHCL-32
dc.subjectPHENOMENOLOGY
dc.titleA multinational study to pilot the modified Hypomania Checklist (mHCL) in the assessment of mixed depression
dc.typeArticle

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