G protein β3 subunit gene polymorphism in Turkish hypertensives
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Date
2008
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Abstract
Objective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein β3 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein β3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein β3 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein β3 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (χ2=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein β3 subunit C825T gene polymorphism is associated with systolic a diastolic blood pressure. Furthermore, the study indicates that the G protein β3 subunit may be a susceptible gene to essential hypertension.
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Adult , Blood Pressure , Case-Control Studies , Cross-Sectional Studies , Female , Gene Frequency , Genotype , Heterotrimeric GTP-Binding Proteins , Humans , Hypertension , Logistic Models , Male , Multivariate Analysis , Polymorphism, Genetic , Risk Factors , Signal Transduction , Turkey , guanine nucleotide binding protein beta subunit , G protein beta3 subunit , G-protein beta3 subunit , heterotrimeric guanine nucleotide binding protein , unclassified drug , adult , article , case control study , controlled study , cross-sectional study , diastolic blood pressure , essential hypertension , female , gene frequency , genetic association , genetic polymorphism , genetic susceptibility , genotype , human , major clinical study , male , polymerase chain reaction , systolic blood pressure , Turkey (republic) , blood pressure , genetic polymorphism , genetics , hypertension , multivariate analysis , risk factor , signal transduction , statistical model