G protein β3 subunit gene polymorphism in Turkish hypertensives

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dc.contributor.authorAlioǧlu E.
dc.contributor.authorErcan E.
dc.contributor.authorTengiz I.
dc.contributor.authorYildiz A.
dc.contributor.authorSaygi U.ö.T.S.
dc.contributor.authorÇam F.S.
dc.contributor.authorBerdeli A.
dc.date.accessioned2024-07-22T08:22:03Z
dc.date.available2024-07-22T08:22:03Z
dc.date.issued2008
dc.description.abstractObjective: G protein is one of the most important regulators of intracellular signaling pathways. C825T polymorphism of G protein β3 subunit is associated with increased intracellular signal transduction. The 825T allele has been found associated with a variety of cardiovascular risk factors, including hypertension. The aim of the present study was to investigate the association between the C825T polymorphism of the G protein β3 subunit and essential hypertension in Turkish population. Methods: This cross-sectional, case-controlled study included 209 patients with essential hypertension (Patient group) and 82 subjects with normal blood pressure (Control group). The G protein β3 subunit C825T gene polymorphism was determined by polymerase chain reaction. Hypertension was defined according to JNC VII criteria. Statistical analysis was performed using Chi square and unpaired t tests. Logistic regression analysis was used to study association between hypertension and genotypes. Results: We found that the frequencies of the G protein β3 subunit C825T polymorphism in hypertensive and control groups were 17.7%, 59.3%, 23.0% and 32.9%, 48.8%, 18.3%, (CC, CT, TT) respectively (χ2=7.963, p=0.019). In the multivariate logistic regression analysis CT genotype had 2.2 (OR=2.262, 95% CI 1.228-4.167, p=0.009), and TT genotype had 2.3 times (OR=2.335, 95% CI 1.089-5.008, p=0.029) greater risk of hypertension compared to CC genotype. Conclusion: It seems that the G protein β3 subunit C825T gene polymorphism is associated with systolic a diastolic blood pressure. Furthermore, the study indicates that the G protein β3 subunit may be a susceptible gene to essential hypertension.
dc.identifier.issn13028723
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18893
dc.language.isoEnglish
dc.subjectAdult
dc.subjectBlood Pressure
dc.subjectCase-Control Studies
dc.subjectCross-Sectional Studies
dc.subjectFemale
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectHeterotrimeric GTP-Binding Proteins
dc.subjectHumans
dc.subjectHypertension
dc.subjectLogistic Models
dc.subjectMale
dc.subjectMultivariate Analysis
dc.subjectPolymorphism, Genetic
dc.subjectRisk Factors
dc.subjectSignal Transduction
dc.subjectTurkey
dc.subjectguanine nucleotide binding protein beta subunit
dc.subjectG protein beta3 subunit
dc.subjectG-protein beta3 subunit
dc.subjectheterotrimeric guanine nucleotide binding protein
dc.subjectunclassified drug
dc.subjectadult
dc.subjectarticle
dc.subjectcase control study
dc.subjectcontrolled study
dc.subjectcross-sectional study
dc.subjectdiastolic blood pressure
dc.subjectessential hypertension
dc.subjectfemale
dc.subjectgene frequency
dc.subjectgenetic association
dc.subjectgenetic polymorphism
dc.subjectgenetic susceptibility
dc.subjectgenotype
dc.subjecthuman
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectpolymerase chain reaction
dc.subjectsystolic blood pressure
dc.subjectTurkey (republic)
dc.subjectblood pressure
dc.subjectgenetic polymorphism
dc.subjectgenetics
dc.subjecthypertension
dc.subjectmultivariate analysis
dc.subjectrisk factor
dc.subjectsignal transduction
dc.subjectstatistical model
dc.titleG protein β3 subunit gene polymorphism in Turkish hypertensives
dc.typeArticle

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