Norfloxacin-induced toxic epidermal necrolysis
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Date
2005
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Abstract
OBJECTIVE: To report a case of toxic epidermal necrolysis (TEN) in a man who was treated with oral norfloxacin for prostatitis. CASE SUMMARY: A 40-year-old man presented with a severe skin reaction, which was diagnosed as TEN. He had received norfloxacin 800 mg/day over a 14-day period for prostatitis and, 10 days after finishing the treatment regimen, he developed cutaneous and mucous lesions typical of TEN. After a prolonged hospitalization and treatment with oral prednisolone therapy, fluid resuscitation, and wound dressing, the man recovered. DISCUSSION: TEN is an infrequent, yet often fatal, severe systemic and cutaneous disease that is most often an adverse drug reaction. There are few case reports of TEN induced by fluoroquinolones. A MEDLINE search (1966-February 2005) revealed no reports of toxic epidermal necrolysis, but one incidence of Stevens-Johnson syndrome due to norfloxacin therapy. An objective causality assessment suggests that TEN was probably related to norfloxacin in this patient. CONCLUSIONS: To our knowledge, this is the first case of TEN associated with the use of oral norfloxacin. We hope that this case report creates awareness that norfloxacin-induced TEN is possible.
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Adult , Epidermal Necrolysis, Toxic , Humans , Male , Norfloxacin , albumin , immunoglobulin , norfloxacin , prednisolone , quinolone derivative , Ringer lactate solution , adult , article , blister , case report , conjunctival hyperemia , convalescence , disease severity , edema , erythema , eye burning , eyelid disease , fluid therapy , hospitalization , human , keratitis , laboratory test , male , mouth lesion , physical examination , priority journal , prostatitis , resuscitation , side effect , skin defect , skin manifestation , toxic epidermal necrolysis , wound dressing