Norfloxacin-induced toxic epidermal necrolysis

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dc.contributor.authorSahin M.T.
dc.contributor.authorOzturkcan S.
dc.contributor.authorInanir I.
dc.contributor.authorFiliz E.E.
dc.date.accessioned2024-07-22T08:24:03Z
dc.date.available2024-07-22T08:24:03Z
dc.date.issued2005
dc.description.abstractOBJECTIVE: To report a case of toxic epidermal necrolysis (TEN) in a man who was treated with oral norfloxacin for prostatitis. CASE SUMMARY: A 40-year-old man presented with a severe skin reaction, which was diagnosed as TEN. He had received norfloxacin 800 mg/day over a 14-day period for prostatitis and, 10 days after finishing the treatment regimen, he developed cutaneous and mucous lesions typical of TEN. After a prolonged hospitalization and treatment with oral prednisolone therapy, fluid resuscitation, and wound dressing, the man recovered. DISCUSSION: TEN is an infrequent, yet often fatal, severe systemic and cutaneous disease that is most often an adverse drug reaction. There are few case reports of TEN induced by fluoroquinolones. A MEDLINE search (1966-February 2005) revealed no reports of toxic epidermal necrolysis, but one incidence of Stevens-Johnson syndrome due to norfloxacin therapy. An objective causality assessment suggests that TEN was probably related to norfloxacin in this patient. CONCLUSIONS: To our knowledge, this is the first case of TEN associated with the use of oral norfloxacin. We hope that this case report creates awareness that norfloxacin-induced TEN is possible.
dc.identifier.DOI-ID10.1345/aph.1E530
dc.identifier.issn10600280
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/19803
dc.language.isoEnglish
dc.subjectAdult
dc.subjectEpidermal Necrolysis, Toxic
dc.subjectHumans
dc.subjectMale
dc.subjectNorfloxacin
dc.subjectalbumin
dc.subjectimmunoglobulin
dc.subjectnorfloxacin
dc.subjectprednisolone
dc.subjectquinolone derivative
dc.subjectRinger lactate solution
dc.subjectadult
dc.subjectarticle
dc.subjectblister
dc.subjectcase report
dc.subjectconjunctival hyperemia
dc.subjectconvalescence
dc.subjectdisease severity
dc.subjectedema
dc.subjecterythema
dc.subjecteye burning
dc.subjecteyelid disease
dc.subjectfluid therapy
dc.subjecthospitalization
dc.subjecthuman
dc.subjectkeratitis
dc.subjectlaboratory test
dc.subjectmale
dc.subjectmouth lesion
dc.subjectphysical examination
dc.subjectpriority journal
dc.subjectprostatitis
dc.subjectresuscitation
dc.subjectside effect
dc.subjectskin defect
dc.subjectskin manifestation
dc.subjecttoxic epidermal necrolysis
dc.subjectwound dressing
dc.titleNorfloxacin-induced toxic epidermal necrolysis
dc.typeArticle

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