Glomerular filtration rate in type 1 diabetic adolescent by using single plasma sample and gamma camera methods
| dc.contributor.author | Aras, F | |
| dc.contributor.author | Bilgin, ES | |
| dc.date.accessioned | 2024-07-18T11:49:49Z | |
| dc.date.available | 2024-07-18T11:49:49Z | |
| dc.description.abstract | Aim: Type-1 diabetes mellitus (DM) has indicated that glomerular hyperfiltration (GFR) is a risk factor for nephropathy. Renal pathological changes develop before features of clinical renal disease including proteinuria and declining GFR are evident. We investigated changes in GFR in children and adolescents with type 1 DM by means of single plasma sample (SPS) and gamma camera Gate's methods using Tc-99m DTPA. Additionally, we determined the specificity, sensitivity, and consistency of the two methods. Material and Methods: Thirty-six patients (mean age: 15.01 +/- 4.03 years) with Type-1 DM (19 males, 17 females) were studied. Impairment of renal function was not detected in any of the patients with routine biochemical tests. Standard Tc-99m DTPA renal images were obtained for 40 minutes and GFR is calculated by Gate's method and values>130/1.73m(2) b.s. were considered hyperfiltration. SPS was obtained at 120 min-post injection and the Cristensen-Groth equation (CG) was used. The patients were divided into two groups according to the duration of diabetes as less than 5 years (Group A) and longer than 5 years (Group B). Results: In Group A, hyperfiltration was detected in 11 of 14 patients with SPS, whereas in 7 of 14 patients with Gate's method. In Group B, hyperfiltration was detected in 17 of 22 patients with SPS, whereas in 13 of 22 patients with Gate's method. Sensitivity of Gate's method was 67.9 % in all patients for diagnosis (Sensitivity: 67.9%, Specificity: 87.5 %, positive predictive value (PPV): 95 %, negative predictive value (NPV): 43.8%). The consistency of these two methods was found as 72.6% (p=0.005). Discussion: Gate's method is useful for clinical practice due to ease of use and high consistency with SPS, especially in the children. SPS remains the first-line method of GFR measurement in suspected diabetic nephropathy patients. | |
| dc.identifier.other | 2667-663X | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4318 | |
| dc.language.iso | English | |
| dc.publisher | BAYRAKOL MEDICAL PUBLISHER | |
| dc.subject | TC-99M DTPA | |
| dc.title | Glomerular filtration rate in type 1 diabetic adolescent by using single plasma sample and gamma camera methods | |
| dc.type | Article |