Possible contribution of leukotrienes in the arrhythmogenic effects of digoxin on isolated guinea-pig hearts
No Thumbnail Available
Date
1998
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The effect of a leukotriene D4 (LTD4) receptor antagonist, L-648,051, was investigated in digoxin-induced cardiac toxicity in isolated guinea-pig hearts (Langendorff preparation). Digoxin infusion (25 μg.ml-1, 0.5 ml.min-1) increased perfusion pressure and contractile force initially, but decreased them later. The onset of first ventricular premature beats (VPBs) matched the increase phase, but the decrease phase was accompanied by ventricular tachycardia (VT) and fibrillation (VF). In the presence of L-648,051 (5 μmol.l-1), the initial phase was similar to that observed with digoxin alone, but the marked reduction was inhibited. This drug increased the concentration of digoxin required for VBSs and cardiac arrest, but it could not prevent the formation of VT and VF. The duration of VT was significantly decreased by L-648,051. It is concluded that the leukotriene receptor antagonist might have beneficial effects on digoxin-induced arrhythmias. Whether this effect depends on direct or indirect actions is uncertain.
Description
Keywords
Animals , Arrhythmia , Digoxin , Guinea Pigs , Heart , Keto Acids , Leukotriene Antagonists , Male , Myocardial Contraction , Organ Culture Techniques , Sulfones , 4 [3 (4 acetyl 3 hydroxy 2 propylphenoxy)propylsulfonyl] 3 oxo 4 phenylbutyric acid , digoxin , leukotriene , animal tissue , arrhythmogenesis , article , cardiotoxicity , controlled study , dose response , drug infusion , guinea pig , heart arrest , heart muscle contractile force , heart muscle perfusion , heart ventricle extrasystole , heart ventricle tachycardia , isolated heart , male , nonhuman , perfusion pressure , priority journal