Possible contribution of leukotrienes in the arrhythmogenic effects of digoxin on isolated guinea-pig hearts

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dc.contributor.authorGök Ş.
dc.contributor.authorÜlker S.
dc.contributor.authorEvinç A.
dc.date.accessioned2024-07-22T08:25:50Z
dc.date.available2024-07-22T08:25:50Z
dc.date.issued1998
dc.description.abstractThe effect of a leukotriene D4 (LTD4) receptor antagonist, L-648,051, was investigated in digoxin-induced cardiac toxicity in isolated guinea-pig hearts (Langendorff preparation). Digoxin infusion (25 μg.ml-1, 0.5 ml.min-1) increased perfusion pressure and contractile force initially, but decreased them later. The onset of first ventricular premature beats (VPBs) matched the increase phase, but the decrease phase was accompanied by ventricular tachycardia (VT) and fibrillation (VF). In the presence of L-648,051 (5 μmol.l-1), the initial phase was similar to that observed with digoxin alone, but the marked reduction was inhibited. This drug increased the concentration of digoxin required for VBSs and cardiac arrest, but it could not prevent the formation of VT and VF. The duration of VT was significantly decreased by L-648,051. It is concluded that the leukotriene receptor antagonist might have beneficial effects on digoxin-induced arrhythmias. Whether this effect depends on direct or indirect actions is uncertain.
dc.identifier.DOI-ID10.1159/000028252
dc.identifier.issn00317012
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20622
dc.language.isoEnglish
dc.subjectAnimals
dc.subjectArrhythmia
dc.subjectDigoxin
dc.subjectGuinea Pigs
dc.subjectHeart
dc.subjectKeto Acids
dc.subjectLeukotriene Antagonists
dc.subjectMale
dc.subjectMyocardial Contraction
dc.subjectOrgan Culture Techniques
dc.subjectSulfones
dc.subject4 [3 (4 acetyl 3 hydroxy 2 propylphenoxy)propylsulfonyl] 3 oxo 4 phenylbutyric acid
dc.subjectdigoxin
dc.subjectleukotriene
dc.subjectanimal tissue
dc.subjectarrhythmogenesis
dc.subjectarticle
dc.subjectcardiotoxicity
dc.subjectcontrolled study
dc.subjectdose response
dc.subjectdrug infusion
dc.subjectguinea pig
dc.subjectheart arrest
dc.subjectheart muscle contractile force
dc.subjectheart muscle perfusion
dc.subjectheart ventricle extrasystole
dc.subjectheart ventricle tachycardia
dc.subjectisolated heart
dc.subjectmale
dc.subjectnonhuman
dc.subjectperfusion pressure
dc.subjectpriority journal
dc.titlePossible contribution of leukotrienes in the arrhythmogenic effects of digoxin on isolated guinea-pig hearts
dc.typeArticle

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