INTRAVITREAL DEXAMETHASONE IMPLANT IN RETINITIS PIGMENTOSA-RELATED CYSTOID MACULAR EDEMA

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dc.contributor.authorMansour, AM
dc.contributor.authorSheheitli, H
dc.contributor.authorKucukerdonmez, C
dc.contributor.authorSisk, RA
dc.contributor.authorMoura, R
dc.contributor.authorMoschos, MM
dc.contributor.authorLima, LH
dc.contributor.authorAl-Shaar, L
dc.contributor.authorArevalo, JF
dc.contributor.authorMaia, M
dc.contributor.authorFoster, RE
dc.contributor.authorKayikcioglu, O
dc.contributor.authorKozak, I
dc.contributor.authorKurup, S
dc.contributor.authorZegarra, H
dc.contributor.authorGallego-Pinazo, R
dc.contributor.authorHamam, RN
dc.contributor.authorBejjani, RA
dc.contributor.authorCinar, E
dc.contributor.authorErakgün, ET
dc.contributor.authorKimura, A
dc.contributor.authorTeixeira, A
dc.date.accessioned2024-07-18T12:08:06Z
dc.date.available2024-07-18T12:08:06Z
dc.description.abstractPurpose: To report the clinical outcome after intravitreal dexamethasone implant in patients with retinitis pigmentosa and cystoid macular edema. Methods: Multicenter retrospective case series of eyes with retinitis pigmentosa and cystoid macular edema that underwent intravitreal dexamethasone implant. Primary outcome measures were best-corrected visual acuity in LogMAR and central macular thickness. Statistical analyses used two-tailed comparison with Wilcoxon signed-rank test. Results: There were a total of 45 eyes from 34 patients with a mean age of 32.7 years (range 16-57) and mean follow-up of 15.5 +/- 13.0 months. At Month 3 after the first injection, mean initial best-corrected visual acuity improved from 0.61 +/- 0.38 (20/81) to 0.37 +/- 0.16 (20/47) (P = 0.012), whereas mean central macular thickness (mu m) decreased from 506 +/- 288 mu m to 311.7 +/- 71.6 mu m (P < 0.001) and mean intraocular pressure increased from 15.7 +/- 2.3 mmHg to 19.8 +/- 11.0 mmHg (P = 0.01). Fourteen eyes had multiple injections (1-7 reinjections) at a mean interval of 6 months. Treatment effect was durable with multiple injections, but with seven eyes developing visually significant cataracts. Conclusion: Best-corrected visual acuity improved up to 4 months in around half of the eyes. Eyes that benefited the most were pseudophakic, steroid nonresponsive, with large initial central macular thickness, and profuse fluorescein dye leakage.
dc.identifier.issn0275-004X
dc.identifier.other1539-2864
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10777
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectOPTICAL COHERENCE TOMOGRAPHY
dc.subjectTRIAMCINOLONE ACETONIDE
dc.subjectVISUAL-ACUITY
dc.subjectASSOCIATION
dc.subjectMANAGEMENT
dc.subjectSECONDARY
dc.titleINTRAVITREAL DEXAMETHASONE IMPLANT IN RETINITIS PIGMENTOSA-RELATED CYSTOID MACULAR EDEMA
dc.typeArticle

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