Topical Ketoprofen Versus Placebo in Children Presenting With Ankle Sprain to the Emergency Department A Randomized Controlled Study
| dc.contributor.author | Serinken, M | |
| dc.contributor.author | Eken, C | |
| dc.contributor.author | Tünay, K | |
| dc.contributor.author | Gölcük, Y | |
| dc.date.accessioned | 2024-07-18T12:05:40Z | |
| dc.date.available | 2024-07-18T12:05:40Z | |
| dc.description.abstract | Objective: Despite the favorable data concerning topical agents use in outpatient clinics, they are not commonly in emergency departments (EDs). The present study aimed to compare the effect of 2.5% topical ketoprofen (gel form) to placebo in children presenting with ankle sprain to the ED. Study Design: Children between 7 and 18 years old presenting with ankle sprain composed the study population. Study patients were randomized into 2 study arms: 2.5% ketoprofen gel and placebo administered in a 5-cm area locally. Pain improvements at 15 and 30 minutes were measured by visual analog scale. Results: Median pain reductions at 15 minutes for ketoprofen and placebo groups were 27.5 (16-39) and 5 (4-10), respectively. Median changes in pain intensity at 30 minutes for ketoprofen and placebo gel groups were 48 (43-52) and 9 (6-16), respectively. When compared 2 arms for the pain improvement at 15 and 30 minutes, the differences between 2 study drugs were 20 (13-28) and 35 (29-41), respectively. There were 7 (12.7%) rescue drug needs in the placebo group and 1 (1.7%) in the ketoprofen group ( difference, 10.9%; 95% confidence interval, -6% to 7%; P = 0.83). There were no adverse effects in either group. Conclusions: Ketoprofen gel is superior to placebo in ceasing pain in children presenting with ankle sprain to the ED with a high safety profile. | |
| dc.identifier.issn | 0749-5161 | |
| dc.identifier.other | 1535-1815 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9916 | |
| dc.language.iso | English | |
| dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | |
| dc.subject | NSAIDS | |
| dc.subject | PAIN | |
| dc.title | Topical Ketoprofen Versus Placebo in Children Presenting With Ankle Sprain to the Emergency Department A Randomized Controlled Study | |
| dc.type | Article |