IL-2R, IL-6 and IL-8 Levels in Behcet's Disease

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dc.contributor.authorInanir, I
dc.contributor.authorOnur, E
dc.contributor.authorPirildar, T
dc.contributor.authorGündüz, K
dc.contributor.authorVar, A
dc.date.accessioned2024-07-18T11:49:51Z
dc.date.available2024-07-18T11:49:51Z
dc.description.abstractBackground and Design: Immunological factors are considered to have an important role in the multifactorial ethiopathogenesis of Behcet's disease (BD). Especially, Th1 cells function by expressing proinflammatory cytokines and neutrophil-attracting chemokines. Levels of IL-2R, IL-6 and IL-8 were evaluated in patients with BD in this study. Material and Method: Sixty-six patients with BD (36 with inactive and 30 with active) composed the study group and 22 subjects the control group. Cytokine analyses were done with ELISA method by using commercial kits. ESR and CRP levels were also measured. Results: IL-2R, IL-6 and IL-8 levels in all patients, including the inactive ones, were not different from those in controls. CRP and ESR levels in patients were higher than in controls. IL-8 and CRP levels were increased in patient with active BD (p<0.05) when compared to those with inactive BD. Conclusion: Our study demonstrated elevated levels of serum IL-8, a chemokine activating monunuclear cells and neutrophils, in patients with active BD. IL-8 may be considered as an activity marker for BD. (Turkderm 2010; 44: 213-5)
dc.identifier.issn2717-6398
dc.identifier.other2651-5164
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4342
dc.language.isoTurkish
dc.publisherDERI ZUHREVI HASTALIKLAR DERNEGI
dc.subjectNECROSIS-FACTOR-ALPHA
dc.subjectC-REACTIVE PROTEIN
dc.subjectSERUM INTERLEUKIN-8
dc.subjectTNF-ALPHA
dc.subjectCYTOKINES
dc.subjectPROFILE
dc.subjectMARKER
dc.subjectCELLS
dc.titleIL-2R, IL-6 and IL-8 Levels in Behcet's Disease
dc.typeArticle

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