Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines
| dc.contributor.author | Fırat F. | |
| dc.contributor.author | Özgül M. | |
| dc.contributor.author | Türköz Uluer E. | |
| dc.contributor.author | Inan S. | |
| dc.date.accessioned | 2025-04-10T11:07:04Z | |
| dc.date.available | 2025-04-10T11:07:04Z | |
| dc.date.issued | 2019 | |
| dc.description.abstract | Cancer is a common cause of death worldwide. Approximately 80% of cancer patients use complementary or alternative medicines for treatment. Caffeic acid phenethyl ester (CAPE), the main active component of propolis, exhibits cytotoxic, antiproliferative and anti-cancer effects. Despite its anticancer effects CAPE exhibits no known harmful effects toward normal cells. We investigated the effects of CAPE on angiogenesis, apoptosis and oxidative stress using MDA MB-231, N2a and COLO 320 cell lines and CAPE treatments at 24 and 48 h. A two dimensional cell culture system was used and the findings were evaluated by an indirect immunohistochemical method and H-scores were calculated. CAPE was effective for all three cancer cell lines. After 24 and 48 h, we found a significant decrease in live cells and increased stress in the cells based on e-NOS and i-NOS levels. © 2019, © 2019 The Biological Stain Commission. | |
| dc.identifier.DOI-ID | 10.1080/10520295.2019.1589574 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/47140 | |
| dc.publisher | Taylor and Francis Ltd | |
| dc.title | Effects of caffeic acid phenethyl ester (CAPE) on angiogenesis, apoptosis and oxidatıve stress ın various cancer cell lines | |
| dc.type | Article |