Antineovascular effect of α-interferon on corneal neovascularization in rats

No Thumbnail Available

Date

2001

Authors

Journal Title

Journal ISSN

Volume Title

Publisher

Abstract

Clinical and histologic effects of topical recombinant α-interferon (IFN), systemic IFN, topical dexamethasone, and dexamethasone plus topical IFN on corneal neovascularization in response to silver nitrate cauterization were investigated in 110 eyes of 60 Wistar rats. The eyes were evaluated according to the burn stimulus, neovascularization, and histologic inflammation grades 5 days after cauterization. Antineovascular effects of topical and systemic IFN were significantly greater than a placebo but less than dexamethasone alone or in combination with IFN.

Description

Keywords

dexamethasone , placebo , recombinant alpha interferon , silver nitrate , animal cell , animal tissue , article , burn , cauterization , controlled study , cornea neovascularization , cornea perforation , drug effect , drug mechanism , inflammation , necrosis , nonhuman , rat

Citation

URI

http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20471

Collections

Scopus Koleksiyonu