Determination of Glycoconjugate Residues of Erythrocytes at Different Age Groups of Rats

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dc.contributor.authorGumus, A
dc.contributor.authorBalcan, E
dc.date.accessioned2024-07-18T11:47:16Z
dc.date.available2024-07-18T11:47:16Z
dc.description.abstractAging is a time-dependent process that contains cell injury caused by molecular damages and eventually functional impairment of tissues and organs. The possible roles of cell surface carbohydrates, which are very important molecules in cell to cell and/or cell to extracellular matrix recognition, on aging process are not yet clear. In this study, glycoconjugate alterations of membrane glycoproteins of erythrocytes in aging organism were evaluated with lectin histochemistry and lectin blotting studies in 1, 4 and 7 months old rats. Lectin histochemistry results indicated that alpha(2 -> 3) and alpha(2 -> 6)-linked sialic acids are intensively found in erythrocyte membranes, but this intensity of sialic acids decreases with age. Similar evidences were obtained from lectin blotting studies which performed with same lectins. These results suggest that sialic acid reactivity alters with the age of organism. We thought that (a) sialic acid containing glycoconjugates altered not only with erythrocyte senescence, but also aging process of organism or (b) the number of sialic acid containing erythrocytes decreased by age.
dc.identifier.issn1306-133X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3383
dc.language.isoEnglish
dc.publisherAKAD DOKTORLAR YAYINEVI
dc.subjectSIALIC-ACID CONTENT
dc.subjectLINKED OLIGOSACCHARIDES
dc.subjectCARBOHYDRATE MOIETY
dc.subjectNEURAMINIDASE TREATMENT
dc.subjectPROTEIN GLYCOSYLATION
dc.subjectBAND-3 GLYCOPROTEIN
dc.subjectSTRUCTURAL-ANALYSIS
dc.subjectIN-VIVO
dc.subjectRECOGNITION
dc.subjectSENESCENT
dc.titleDetermination of Glycoconjugate Residues of Erythrocytes at Different Age Groups of Rats
dc.typeArticle

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