Prevalence of the angiotensin i converting enzyme gene insertion/deletion polymorphism in a healthy turkish population
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2009
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Abstract
Angiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations. © 2009 Springer Science+Business Media, LLC.
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Adult , Alleles , Gene Frequency , Genotype , Humans , INDEL Mutation , Peptidyl-Dipeptidase A , Polymorphism, Genetic , Turkey , Young Adult , dipeptidyl carboxypeptidase , adult , article , Caucasian , controlled study , gene frequency , genotype , human , indel mutation , normal human , polymerase chain reaction , prevalence , protein function , Turkey (republic)