Prevalence of the angiotensin i converting enzyme gene insertion/deletion polymorphism in a healthy turkish population

Simple item page
dc.contributor.authorBerdeli A.
dc.contributor.authorCam F.S.
dc.date.accessioned2024-07-22T08:21:42Z
dc.date.available2024-07-22T08:21:42Z
dc.date.issued2009
dc.description.abstractAngiotensin converting enzyme (ACE) plays an essential role in the renin-angiotensin system. It converts angiotensin I to angiotensin II and inactivates bradykinin and tachykinins. Numerous studies have been published investigating associations of the ACE gene I/D polymorphism with various pathophysiological conditions. We examined the prevalence of the ACE I/D polymorphism in a sample of healthy volunteers from western Turkey, including 1063 healthy Turkish controls. Analysis of the ACE I/D gene polymorphisms by polymerase chain reaction found frequencies of 16.1% for the II genotype, 47.7% for the ID genotype, and 36.2% for the DD genotype. The allele frequency was 39.9% for the I alleles and 60.1% for the D allele. This study demonstrates that the allele and genotype frequency values for the Turkish population are similar to previously published frequencies for Caucasian populations. © 2009 Springer Science+Business Media, LLC.
dc.identifier.DOI-ID10.1007/s10528-009-9240-8
dc.identifier.issn00062928
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/18745
dc.language.isoEnglish
dc.subjectAdult
dc.subjectAlleles
dc.subjectGene Frequency
dc.subjectGenotype
dc.subjectHumans
dc.subjectINDEL Mutation
dc.subjectPeptidyl-Dipeptidase A
dc.subjectPolymorphism, Genetic
dc.subjectTurkey
dc.subjectYoung Adult
dc.subjectdipeptidyl carboxypeptidase
dc.subjectadult
dc.subjectarticle
dc.subjectCaucasian
dc.subjectcontrolled study
dc.subjectgene frequency
dc.subjectgenotype
dc.subjecthuman
dc.subjectindel mutation
dc.subjectnormal human
dc.subjectpolymerase chain reaction
dc.subjectprevalence
dc.subjectprotein function
dc.subjectTurkey (republic)
dc.titlePrevalence of the angiotensin i converting enzyme gene insertion/deletion polymorphism in a healthy turkish population
dc.typeArticle

Files

Collections

Scopus Koleksiyonu