E-Cadherin: An Important Functional Molecule at Respiratory Barrier Between Defence and Dysfunction
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Date
2021
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Abstract
While breathing, many microorganisms, harmful environmental particles, allergens, and environmental pollutants enter the human airways. The human respiratory tract is lined with epithelial cells that act as a functional barrier to these harmful factors and provide homeostasis between external and internal environment. Intercellular epithelial junctional proteins play a role in the formation of the barrier. E-cadherin is a calcium-dependent adhesion molecule and one of the most important molecules involved in intercellular epithelial barier formation. E-cadherin is not only physical barrier element but also regulates cell proliferation, differentiation and the immune response to environmental noxious agents through various transcription factors. In this study, we aimed to review the role of E-cadherin in the formation of airway epithelial barier, its status as a result of exposure to various environmental triggers, and respiratory diseases associated with its dysfunction. Moreover, the situations in which its abnormal activation can be noxious would be discussed. © Copyright © 2021 Yuksel, Ocalan and Yilmaz.
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Keywords
transcription factor , uvomorulin , adherens junction , adult respiratory distress syndrome , asthma , cell differentiation , cell proliferation , chronic obstructive lung disease , environmental factor , epithelial mesenchymal transition , epithelium cell , fibrosing alveolitis , homeostasis , human , immune response , nonhuman , pollutant , protein function , regulatory mechanism , respiratory epithelium , respiratory failure , respiratory function , respiratory tract disease , Review , tissue structure