E-Cadherin: An Important Functional Molecule at Respiratory Barrier Between Defence and Dysfunction

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dc.contributor.authorYuksel H.
dc.contributor.authorOcalan M.
dc.contributor.authorYilmaz O.
dc.date.accessioned2024-07-22T08:05:21Z
dc.date.available2024-07-22T08:05:21Z
dc.date.issued2021
dc.description.abstractWhile breathing, many microorganisms, harmful environmental particles, allergens, and environmental pollutants enter the human airways. The human respiratory tract is lined with epithelial cells that act as a functional barrier to these harmful factors and provide homeostasis between external and internal environment. Intercellular epithelial junctional proteins play a role in the formation of the barrier. E-cadherin is a calcium-dependent adhesion molecule and one of the most important molecules involved in intercellular epithelial barier formation. E-cadherin is not only physical barrier element but also regulates cell proliferation, differentiation and the immune response to environmental noxious agents through various transcription factors. In this study, we aimed to review the role of E-cadherin in the formation of airway epithelial barier, its status as a result of exposure to various environmental triggers, and respiratory diseases associated with its dysfunction. Moreover, the situations in which its abnormal activation can be noxious would be discussed. © Copyright © 2021 Yuksel, Ocalan and Yilmaz.
dc.identifier.DOI-ID10.3389/fphys.2021.720227
dc.identifier.issn1664042X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/13099
dc.language.isoEnglish
dc.publisherFrontiers Media S.A.
dc.rightsAll Open Access; Gold Open Access; Green Open Access
dc.subjecttranscription factor
dc.subjectuvomorulin
dc.subjectadherens junction
dc.subjectadult respiratory distress syndrome
dc.subjectasthma
dc.subjectcell differentiation
dc.subjectcell proliferation
dc.subjectchronic obstructive lung disease
dc.subjectenvironmental factor
dc.subjectepithelial mesenchymal transition
dc.subjectepithelium cell
dc.subjectfibrosing alveolitis
dc.subjecthomeostasis
dc.subjecthuman
dc.subjectimmune response
dc.subjectnonhuman
dc.subjectpollutant
dc.subjectprotein function
dc.subjectregulatory mechanism
dc.subjectrespiratory epithelium
dc.subjectrespiratory failure
dc.subjectrespiratory function
dc.subjectrespiratory tract disease
dc.subjectReview
dc.subjecttissue structure
dc.titleE-Cadherin: An Important Functional Molecule at Respiratory Barrier Between Defence and Dysfunction
dc.typeReview

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