N-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver

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dc.contributor.authorKilciksiz, S
dc.contributor.authorDemirel, C
dc.contributor.authorAyhan, SE
dc.contributor.authorErdal, N
dc.contributor.authorGurgul, S
dc.contributor.authorTamer, L
dc.contributor.authorAyaz, L
dc.date.accessioned2024-07-18T12:03:57Z
dc.date.available2024-07-18T12:03:57Z
dc.description.abstractPurpose: The present study was designed to investigate the potential radioprotective effects of N-acetylcysteine (NAC) on radiation-induced nitrosative stress caused by gamma irradiation (single dose, 6 Gy) in rat liver Methods: The rats (n=40) were divided randomly and equally into 4 groups: Control (C), Radiation (R), R+NAC (received irradiation and 1,000 mg/kg of NAC) and R+WR-2721 (received irradiation and 200 mg/kg of WR-2721). Liver tissue of each animal was harvested and utilized for 3-nitrotyrosine (3-NT) detection using high-performance liquid chromatography-ultraviolet (HPLC-UV) system. Results: In the R rats, 3-NT levels significantly increased when compared to those of the C rats (p<0.05). There were no significant differences in the 3-NT levels among R+NAC and R+WR-2721 rats. Histologically examined liver tissue samples showed no obvious differences. Conclusion: The present study suggests that irradiation has a negative effect on the cellular proteins by enhancing 3-NT formation. The prophylactic use of NAC seems to reduce the nitrosative damage during radiotherapy.
dc.identifier.issn1107-0625
dc.identifier.other2241-6293
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9469
dc.language.isoEnglish
dc.publisherZERBINIS MEDICAL PUBL
dc.subjectPROTEIN-TYROSINE NITRATION
dc.subjectNITRIC-OXIDE PRODUCTION
dc.subjectSUPEROXIDE-DISMUTASE
dc.subjectOXIDATIVE STRESS
dc.subjectFREE-RADICALS
dc.subject3-NITROTYROSINE
dc.subjectTISSUE
dc.subjectCYTOTOXICITY
dc.subjectANTIOXIDANTS
dc.subjectENDOTHELIUM
dc.titleN-acetylcysteine ameliorates nitrosative stress on radiation-inducible damage in rat liver
dc.typeArticle

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