Decreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus

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dc.contributor.authorAkbas, M
dc.contributor.authorKoltan, SO
dc.contributor.authorKoyuncu, FM
dc.contributor.authorUlkumen, BA
dc.contributor.authorTaneli, F
dc.contributor.authorOzdemir, H
dc.date.accessioned2024-07-18T11:39:24Z
dc.date.available2024-07-18T11:39:24Z
dc.description.abstractObjective: To investigate serum cortistatin levels in women with gestational diabetes mellitus (GDM) and women with uncomplicated pregnancies. Material and methods: This case-control study consisted of 40 pregnancies with GDM and 41 healthy singleton pregnancies matched for maternal and gestational age. The maternal serum levels of cortistatin were measured with enzyme-linked immunosorbent assay and compared between groups. Results: Cortistatin levels were significantly lower in GDM group (48.85 +/- 20.18 versus 65.84 +/- 33.98 ng/ml, p = .008). There was a statistically significant difference in cortistatin levels between different treatment modalities and control group (chi(2)(2) = 8.828, p = .012). Pairwise comparisons showed that diet group had significantly lower CST levels than control group (p = .012). Serum cortistatin levels were negatively correlated with serum insulin and glucose levels and HOMA-IR (r = -0.358, p = .001; r = -0.303, p = .006; r = -0.444, p < .001, respectively). Conclusion: Cortistatin levels were significantly lower in GDM pregnancies and related to serum insulin and glucose levels and HOMA-IR in pregnancy. This may help to better clarify the mechanism of GDM pathogenesis.
dc.identifier.issn1476-7058
dc.identifier.other1476-4954
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/1606
dc.language.isoEnglish
dc.publisherTAYLOR & FRANCIS LTD
dc.subjectBETA-CELL FUNCTION
dc.subjectSOMATOSTATIN RECEPTORS
dc.subjectEXPRESSION
dc.subjectHYPERGLYCEMIA
dc.subjectNEUROPEPTIDE
dc.subjectSTRESS
dc.subjectGH
dc.titleDecreased maternal serum cortistatin levels in pregnancies with gestational diabetes mellitus
dc.typeArticle

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