Serum tumor growth factor-β1 levels in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C

Simple item page
dc.contributor.authorKirmaz, C
dc.contributor.authorTerzioglu, E
dc.contributor.authorTopalak, O
dc.contributor.authorBayrak, P
dc.contributor.authorYilmaz, O
dc.contributor.authorErsoz, G
dc.contributor.authorSebik, F
dc.date.accessioned2024-07-18T12:06:00Z
dc.date.available2024-07-18T12:06:00Z
dc.description.abstractChronic liver disease and cirrhosis are two of the most important health problems according to current gastroenterology literature. Based on the recent developments in the field of immunology, advanced follow-up and treatment modalities have been introduced for these disorders. Immune defence against viral infections depends on effective cellular immune responses derived mainly from Th1-related cytokines. Th2 type immune responses can inhibit efficient immune function by secretion of several cytokines such as IL-10, TGF-beta1. In this particular study, we determined the serum levels of TGF-beta1, which plays a role in immune suppression and induction of tissue fibrosis. We evaluated the role of TGF-beta1 in the pathogenesis of chronic liver disease and cirrhosis. Fourteen chronic hepatitis B (CHB), 12 chronic hepatitis C (CHC) patients and 21 cirrhotic patients were enrolled in the study. The control group consisted of ten healthy people. Serum TGF-beta1 levels were higher in both cirrhosis and CHC group when compared to those in CHB and control groups (P < 0.05). Although serum TGF-beta1 levels in the cirrhosis group were higher than that in the CHC group, the difference was not statistically significant. In conclusion, elevated TGF-beta1 levels in patients with CHC and cirrhosis may have a role in the pathogenesis and chronicity of these diseases.
dc.identifier.issn1148-5493
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10125
dc.language.isoEnglish
dc.publisherJOHN LIBBEY EUROTEXT LTD
dc.subjectCHRONIC LIVER-DISEASE
dc.subjectFACTOR-BETA
dc.subjectTRANSFORMING GROWTH-FACTOR-BETA-1
dc.subjectVIRUS-INFECTION
dc.subjectNECROSIS-FACTOR
dc.subjectDNA-SYNTHESIS
dc.subjectIN-VITRO
dc.subjectINHIBITION
dc.subjectCELLS
dc.subjectHEPATOCYTES
dc.titleSerum tumor growth factor-β1 levels in patients with cirrhosis, chronic hepatitis B and chronic hepatitis C
dc.typeArticle

Files

Collections

Web of Science Koleksiyonu