Immunolocalization of αV, α3 and β1 integrins in the human placenta with pre-eclampsia
| dc.contributor.author | Vatansever, HS | |
| dc.contributor.author | Inan, VS | |
| dc.contributor.author | Lacin, S | |
| dc.contributor.author | Koyuncu, F | |
| dc.date.accessioned | 2024-07-18T11:49:18Z | |
| dc.date.available | 2024-07-18T11:49:18Z | |
| dc.description.abstract | Signs of pre-eclampsia are considered to be caused by maternal endothelial dysfunction due to circulating factors of placental origin. Integrins are a large family of cell surface proteins that serve as receptors involved in cell-cell and cell-matrix interactions during placentation. Therefore, low expression of integrins or the lack of it may be encountered during pre-eclampsia. In the present study, we investigated the immunolocalisation of integrins alphaV, alpha3 and beta1 in placentas of normal and preeclamptic women. Thirty-two placentas from pre-eclamptic (n = 14) and normotensive (n = 18) women were used. Immunohistochemical staining was performed on formalin-fixed, paraffin-embedded tissue specimens, using anti-alphaV, anti-alpha3 and anti-beta1 antibodies and the indirect immunoperoxidase technique. A semi-quantitative grading system (HSCORE) was used to compare immunohistochemical staining intensities. Distribution patterns of alphaV, alpha3 and beta1 integrins were detected in cytotrophoblasts and Hofbauer cells in normal and pre-eclamptic placentas. Immunostaining of alphaV and beta1 integrins was slightly decreased in pre-eclamptic samples but alpha3 integrin immunostaining was similar in pre-eclamptic and normal placentas. Decreased immunostaining of integrins in the cytotrophoblasts may considered to be a structural basis for decreased placental perfusion in pre-eclampsia. | |
| dc.identifier.issn | 0065-1281 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3930 | |
| dc.language.iso | English | |
| dc.publisher | URBAN & FISCHER VERLAG | |
| dc.subject | ADHESION MOLECULES | |
| dc.subject | CELL-ADHESION | |
| dc.subject | INTEGRINS | |
| dc.subject | EXPRESSION | |
| dc.subject | TROPHOBLAST | |
| dc.subject | IMPLANTATION | |
| dc.subject | DIFFERENTIATION | |
| dc.subject | FIBRONECTIN | |
| dc.subject | ENDOMETRIUM | |
| dc.subject | INVASION | |
| dc.title | Immunolocalization of αV, α3 and β1 integrins in the human placenta with pre-eclampsia | |
| dc.type | Article; Proceedings Paper |