Tyrosine kinase inhibition and chemotherapy; [Tirozin kinaz i̇nhibisyonu ve kemoterapi]
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Date
2004
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Abstract
Breast cancer is the most common tumor in women and causes 18% of the cancer related deaths among women in the USA. The five year survival rate of metastatic breast cancer is only 18%. The treatment remains incurable with standard chemotherapy. Epidermal Growth Factor - Receptor (EGF-R) shows tyrosine kinase activity which has been suggested play an significant role on the cell proliferation. Many types of cancer, specially breast cancer, display enhanced EGF-R expression on cell surface membranes. EGF-Receptor may be a suitable target and the inhibitors of protein tyrosine kinases may be useful for therapy of metastatic breast cancer. Genistein (Gen) is a tyrosine kinase inhibitor. Recent studies demonstrated that the conjugation of EGF and Genistein (EGF-Gen) has a cytotoxic activity against breast cancer cells. The specific aim of this study is to examine the anti-tumor efficacy of EGF-Gen conjugate, side by side with standard chemotherapeutic agents (methotrexate, adriamycin, and cyclophosphamide) and the combine activity of EGF-Gen conjugate with standard chemotherapeutic agents in a SCID mouse xenograft model of human breast cancer.
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Keywords
cyclophosphamide , doxorubicin , epidermal growth factor receptor , genistein , methotrexate , protein tyrosine kinase inhibitor , article , breast cancer , breast metastasis , cancer combination chemotherapy , cancer epidemiology , cancer mortality , cancer survival , cytotoxicity , drug efficacy , enzyme activity , enzyme inhibition , human , nonhuman , protein expression , survival rate , United States