Tyrosine kinase inhibition and chemotherapy; [Tirozin kinaz i̇nhibisyonu ve kemoterapi]

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dc.contributor.authorZeren T.
dc.contributor.authorEkerbiçer N.
dc.date.accessioned2024-07-22T08:24:36Z
dc.date.available2024-07-22T08:24:36Z
dc.date.issued2004
dc.description.abstractBreast cancer is the most common tumor in women and causes 18% of the cancer related deaths among women in the USA. The five year survival rate of metastatic breast cancer is only 18%. The treatment remains incurable with standard chemotherapy. Epidermal Growth Factor - Receptor (EGF-R) shows tyrosine kinase activity which has been suggested play an significant role on the cell proliferation. Many types of cancer, specially breast cancer, display enhanced EGF-R expression on cell surface membranes. EGF-Receptor may be a suitable target and the inhibitors of protein tyrosine kinases may be useful for therapy of metastatic breast cancer. Genistein (Gen) is a tyrosine kinase inhibitor. Recent studies demonstrated that the conjugation of EGF and Genistein (EGF-Gen) has a cytotoxic activity against breast cancer cells. The specific aim of this study is to examine the anti-tumor efficacy of EGF-Gen conjugate, side by side with standard chemotherapeutic agents (methotrexate, adriamycin, and cyclophosphamide) and the combine activity of EGF-Gen conjugate with standard chemotherapeutic agents in a SCID mouse xenograft model of human breast cancer.
dc.identifier.issn10165134
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/20053
dc.language.isoTurkish
dc.subjectcyclophosphamide
dc.subjectdoxorubicin
dc.subjectepidermal growth factor receptor
dc.subjectgenistein
dc.subjectmethotrexate
dc.subjectprotein tyrosine kinase inhibitor
dc.subjectarticle
dc.subjectbreast cancer
dc.subjectbreast metastasis
dc.subjectcancer combination chemotherapy
dc.subjectcancer epidemiology
dc.subjectcancer mortality
dc.subjectcancer survival
dc.subjectcytotoxicity
dc.subjectdrug efficacy
dc.subjectenzyme activity
dc.subjectenzyme inhibition
dc.subjecthuman
dc.subjectnonhuman
dc.subjectprotein expression
dc.subjectsurvival rate
dc.subjectUnited States
dc.titleTyrosine kinase inhibition and chemotherapy; [Tirozin kinaz i̇nhibisyonu ve kemoterapi]
dc.typeArticle

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