A comparative study of azithromycin, cephalexin and penicillin V for the treatment of streptococcal pharyngitis and tonsillitis in children; [COCUKLARDA STREPTOKOKSIK FARENJIT VE TONSILLIT TEDAVISINDE AZITROMISIN, SEFALEKSIN VE ORAL PENISILIN VNIN ETKINLIGININ KARSILASTIRILMASI]
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1996
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Abstract
In this study, clinical and bacteriological efficacies of penicillin V were compared with those of azithromycin and cephalexin. Of 94 children who had group A beta hemolytic streptococcal (GABHS) pharyngitis/tonsillitis, 31 received a single daily. dose of azithromycin (10 mg/kg) for three days, 33 received cephalexin 40 mg/kg/day in three doses for 10 days, 30 received oral penicillin V 50.000 IU/kg for 10 days. At the end of the treatment, bacterial eradication was achieved in 91% of azithromycin-treated patients, 88% of cephalexin-treated patients and 83% of penicillin treated-patients (p > 0.05). Clinical cure rates were 94% in azithromycin group, 91% in cephalexin group and 90% in penicillin group (p > 0.05). At follow-up evaluation (day 30 ± 5) bacteriologic recurrence was observed in 4 patients of azithromycin-treated group (13%), in 6 of cephalexin treated group (18%) and in 6 of penicillin-treated group (20%). The results of this study indicate that oral penicillin V is clinically as effective as azithromycin and cephalexin in the treatment of GABHS pharyngotonsillitis.
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azithromycin , cefalexin , penicillin v , adolescent , article , child , drug efficacy , female , hemolytic streptococcus , human , infant , major clinical study , male , oral drug administration , pharyngitis , tonsillitis