Preparation, in vitro mineralization and osteoblast cell response of electrospun 13-93 bioactive glass nanofibers

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dc.contributor.authorDeliormanli A.M.
dc.date.accessioned2024-07-22T08:13:15Z
dc.date.available2024-07-22T08:13:15Z
dc.date.issued2015
dc.description.abstractIn this study, silicate based 13-93 bioactive glass fibers were prepared through sol-gel processing and electrospinning technique. A precursor solution containing poly (vinyl alcohol) and bioactive glass sol was used to produce fibers. The mixture was electrospun at a voltage of 20 kV by maintaining tip to a collector distance of 10 cm. The amorphous glass fibers with an average diameter of 464 ± 95 nm were successfully obtained after calcination at 625 °C. Hydroxyapatite formation on calcined 13-93 fibers was investigated in simulated body fluid (SBF) using two different fiber concentrations (0.5 and 1 mg/ml) at 37 °C. When immersed in SBF, conversion to a calcium phosphate material showed a strong dependence on the fiber concentration. At 1 mg/ml, the surface of the fibers converted to the hydroxyapatite-like material in SBF only after 30 days. At lower solid concentrations (0.5 mg/ml), an amorphous calcium phosphate layer formation was observed followed by the conversion to hydroxyapatite phase after 7 days of immersion. The XTT (2,3-Bis-(2-Methoxy-4-Nitro-5-Sulfophenyl)-2H-Tetrazolium-5-Carboxanilide) assay was conducted to evaluate the osteoblast cell response to the bioactive glass fibers. © 2015 Elsevier B.V. All rights reserved.
dc.identifier.DOI-ID10.1016/j.msec.2015.04.037
dc.identifier.issn09284931
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16305
dc.language.isoEnglish
dc.publisherElsevier Ltd
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAnimals
dc.subjectBiocompatible Materials
dc.subjectCell Line
dc.subjectCell Survival
dc.subjectElectrochemical Techniques
dc.subjectGlass
dc.subjectMice
dc.subjectNanofibers
dc.subjectOsteoblasts
dc.subjectParticle Size
dc.subjectSurface Properties
dc.subjectCalcination
dc.subjectCalcium
dc.subjectCalcium phosphate
dc.subjectCells
dc.subjectElectrospinning
dc.subjectFibers
dc.subjectGlass fibers
dc.subjectHydroxyapatite
dc.subjectPolyvinyl alcohols
dc.subjectSilicates
dc.subjectSol-gel process
dc.subjectSol-gels
dc.subjectSpinning (fibers)
dc.subjectTissue engineering
dc.subject13-93 bioactive glass
dc.subjectbiomaterial
dc.subjectglass
dc.subjectnanofiber
dc.subjectAmorphous calcium phosphate
dc.subjectCalcium phosphate materials
dc.subjectElectrospinning techniques
dc.subjectHydroxyapatite formations
dc.subjectPrecursor solutions
dc.subjectSimulated body fluids
dc.subjectSolid concentrations
dc.subjectTissue engineering applications
dc.subjectanimal
dc.subjectcell line
dc.subjectcell survival
dc.subjectchemistry
dc.subjectdrug effects
dc.subjectelectrochemical analysis
dc.subjectmouse
dc.subjectosteoblast
dc.subjectparticle size
dc.subjectsurface property
dc.subjectBioactive glass
dc.titlePreparation, in vitro mineralization and osteoblast cell response of electrospun 13-93 bioactive glass nanofibers
dc.typeArticle

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