Congenital hypomelanoses: Review; [Konjenital hipomelanozlar]
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Date
2011
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Abstract
Congenital hypomelanoses are pigmentary disorders that are seen in early infancy or childhood, and they can be either restricted to skin or associated with systemic manifestations. In early childhood, many of these disorders have a genetic origin and present with generalized pigmentary dilution. Other clinical features such as the sites of involvement, degree of pigment loss, and associated morphological signs can help in the further differentiation of these disorders. In this article, congenital hypomelanoses and their differential diagnoses are reviewed under the subtitles of generalized hypopigmentation disorders (oculocutaneous albinism, Prader-Willi and Angelman syndromes, Hermansky-Pudlak syndrome, Chediak-Higashi syndrome, Cross syndrome, phenylketonuria, Griscelli syndrome, Elejalde syndrome, Menkes syndrome, Ectrodactyly-Ectodermal dysplasia and clefting of lip and palate syndrome) and localized hypopigmentation disorders (Piebaldism, Waardenburg syndrome, tuberosus sclerosis, nevus depigmentosus, hypomelanosis of Ito). Copyright © 2011 by Türkiye Klinikleri.