Never in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer

Simple item page
dc.contributor.authorGerçeker E.
dc.contributor.authorBoyacioglu S.O.
dc.contributor.authorKasap E.
dc.contributor.authorBaykan A.
dc.contributor.authorYuceyar H.
dc.contributor.authorYildirim H.
dc.contributor.authorAyhan S.
dc.contributor.authorEllidokuz E.
dc.contributor.authorKorkmaz M.
dc.date.accessioned2024-07-22T08:12:58Z
dc.date.available2024-07-22T08:12:58Z
dc.date.issued2015
dc.description.abstractUlcerative colitis (UC) is an important risk factor for colorectal cancer (CRC). Histone modifications are one of the epigenetic mechanisms that may have key roles in the carcinogenesis of CRC. At present, there are no studies comparing histone modification patterns of UC and CRC in the literature. Therefore the aim of the present study was to investigate whether genes, particularly those involved in histone modification, have value in patient monitoring with regards to CRC development in UC. Key gene expressions of the histone modification enzyme were assessed and compared in CRC, UC and control groups using the RT-PCR array technique. Patients were divided into subgroups based on the extent and duration of the disease and inflammatory burden, which are considered risk factors for CRC development in UC patients. In UC and CRC groups, a significantly higher overexpression of the NEK6 and AURKA genes compared to the control group was identified. In addition, there was a significantly higher overexpression of HDAC1 and PAK1 genes in the UC group, and of HDAC1, HDAC7, PAK1 and AURKB genes in the CRC group. NEK6, AURKA, HDAC1 and PAK1 were significantly overexpressed in patients with a longer UC duration. Overexpression of AURKA and NEK6 genes was significantly more pronounced in UC patients with more extensive colon involvement. HDAC1, HDAC7, PAK1, NEK6, AURKA and AURKB are important diagnostic and prognostic markers involved in the carcinogenesis of CRC. HDAC1, PAK1, NEK6 and AURKA may be considered as diagnostic markers to be used in CRC screening for UC patients.
dc.identifier.DOI-ID10.3892/or.2015.4187
dc.identifier.issn1021335X
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/16245
dc.language.isoEnglish
dc.publisherSpandidos Publications
dc.rightsAll Open Access; Bronze Open Access
dc.subjectAdult
dc.subjectAged
dc.subjectAurora Kinase A
dc.subjectBiomarkers, Tumor
dc.subjectCell Transformation, Neoplastic
dc.subjectColitis, Ulcerative
dc.subjectColorectal Neoplasms
dc.subjectDNA Methylation
dc.subjectEpigenesis, Genetic
dc.subjectFemale
dc.subjectHistone Code
dc.subjectHistone Deacetylase 1
dc.subjectHistone Deacetylases
dc.subjectHumans
dc.subjectMale
dc.subjectMiddle Aged
dc.subjectp21-Activated Kinases
dc.subjectProtein-Serine-Threonine Kinases
dc.subjectaurora A kinase
dc.subjectbiological marker
dc.subjecthistone deacetylase 1
dc.subjecthistone deacetylase 7
dc.subjectp21 activated kinase 1
dc.subjectaurora A kinase
dc.subjectHDAC1 protein, human
dc.subjectHDAC7 protein, human
dc.subjecthistone deacetylase
dc.subjecthistone deacetylase 1
dc.subjectNEK6 protein, human
dc.subjectp21 activated kinase
dc.subjectPAK1 protein, human
dc.subjectprotein serine threonine kinase
dc.subjecttumor marker
dc.subjectadult
dc.subjectArticle
dc.subjectAURKB gene
dc.subjectaurora kinase A gene
dc.subjectcancer growth
dc.subjectcancer prognosis
dc.subjectcancer risk
dc.subjectcolon carcinogenesis
dc.subjectcolorectal cancer
dc.subjectcontrolled study
dc.subjectdisease duration
dc.subjectdisease severity
dc.subjectenzyme analysis
dc.subjectfemale
dc.subjectgene overexpression
dc.subjectgenetic analysis
dc.subjectHDAC1 gene
dc.subjectHDAC7 gene
dc.subjecthistone modification
dc.subjecthistopathology
dc.subjecthuman
dc.subjecthuman tissue
dc.subjectmajor clinical study
dc.subjectmale
dc.subjectmalignant transformation
dc.subjectnever in mitosis gene A related kinase 6 gene
dc.subjectPAK1 gene
dc.subjectpatient monitoring
dc.subjectpriority journal
dc.subjectreverse transcription polymerase chain reaction
dc.subjectulcerative colitis
dc.subjectaged
dc.subjectbiosynthesis
dc.subjectcell transformation
dc.subjectColorectal Neoplasms
dc.subjectcomplication
dc.subjectDNA methylation
dc.subjectgenetic epigenesis
dc.subjectgenetics
dc.subjecthistone code
dc.subjectmiddle aged
dc.subjectpathology
dc.subjectulcerative colitis
dc.titleNever in mitosis gene A-related kinase 6 and aurora kinase A: New gene biomarkers in the conversion from ulcerative colitis to colorectal cancer
dc.typeArticle

Files

Collections

Scopus Koleksiyonu