The effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma

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dc.contributor.authorOcal, FCA
dc.contributor.authorKesici, GG
dc.contributor.authorGurgen, SG
dc.contributor.authorOcal, R
dc.contributor.authorErbek, S
dc.date.accessioned2024-07-18T12:02:50Z
dc.date.available2024-07-18T12:02:50Z
dc.description.abstractObjective To investigate whether oxytocin can prevent ototoxicity related to acoustic trauma. Methods Twenty-eight rats were divided into four groups: noise (group 1), control (group 2), noise plus oxytocin (group 3), and oxytocin (group 4). Intratympanic oxytocin was administered on days 1, 2, 4, 6, 8 and 10 in groups 3 and 4. Groups 1 and 3 were exposed to acoustic trauma. Distortion product otoacoustic emission and auditory brainstem response testing were performed in all groups. Results In group 1, auditory brainstem response thresholds increased significantly after acoustic trauma. In group 3, auditory brainstem response thresholds increased significantly on day 1 after acoustic trauma, but there were no significant differences between thresholds at baseline and on the 7th and 21st days. In group 1, significant differences were observed between distortion product otoacoustic emission signal-to-noise ratios measured before and on days 1, 7 and 21 after acoustic trauma. In group 3, no significant differences were observed between the distortion product otoacoustic emission signal-to-noise ratios measured before and on days 7 and 21 after acoustic trauma. Conclusion Oxytocin had a therapeutic effect on rats exposed to acoustic trauma in this experiment.
dc.identifier.issn0022-2151
dc.identifier.other1748-5460
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/8708
dc.language.isoEnglish
dc.publisherCAMBRIDGE UNIV PRESS
dc.subjectINDUCED HEARING-LOSS
dc.subjectINNER-EAR
dc.subjectNOISE EXPOSURE
dc.subjectDAMAGE
dc.subjectNEPHROTOXICITY
dc.subjectINHIBITION
dc.subjectDELIVERY
dc.subjectCOCHLEA
dc.subjectINJURY
dc.subjectGENE
dc.titleThe effect of intratympanic oxytocin treatment on rats exposed to acoustic trauma
dc.typeArticle; Proceedings Paper

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