Radiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging

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dc.contributor.authorUyaroğlu Ö.
dc.contributor.authorDemiroğlu H.
dc.contributor.authorTopal G.
dc.contributor.authorParlak Y.
dc.contributor.authorGül Gümüşer F.
dc.contributor.authorUluer Türköz E.
dc.contributor.authorDemir V.
dc.contributor.authorAteş B.
dc.contributor.authorÜnak P.
dc.contributor.authorAvcıbaşı U.
dc.date.accessioned2025-04-10T11:08:25Z
dc.date.available2025-04-10T11:08:25Z
dc.date.issued2017
dc.description.abstractThe aim of this study was to prepare 99mTc-Sulfamethoxazole complex and evaluate its efficiency as an infection imaging agent. The Sulfamethoxazole was labeled with 99mTc and its biological efficacy as a potential radio tracer for Staphylococcus aureus infection was investigated in bacterially infected Albino Wistar rats. The radiolabeling yield was found to be 95 ± 3.07% and remained constant at more than 93 ± 0.1% even in serum for 240 min after radiolabeling. 99mTc-Sulfamethoxazole prepared with high yield localized well in the bacterially infected muscle of the rats. 99mTc-Sulfamethoxazole may be developed as a radiopharmaceutical agent to distinguish infection from inflammation by nuclear imaging. © 2017, Springer Science+Business Media, LLC.
dc.identifier.DOI-ID10.1007/s00044-017-2009-4
dc.identifier.urihttp://hdl.handle.net/20.500.14701/48017
dc.publisherBirkhauser Boston
dc.titleRadiosynthesis and biodistribution of 99mTc-Sulfamethoxazole: a novel molecule for in-vivo infection imaging
dc.typeArticle

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