Second-line drug susceptibilities of multidirug-resistant Mycobacterium tuberculosis isolates in Aegean region - Turkey
| dc.contributor.author | Özkütük, N | |
| dc.contributor.author | Sürücüoglu, S | |
| dc.contributor.author | Gazi, H | |
| dc.contributor.author | Coskun, M | |
| dc.contributor.author | Özkütük, A | |
| dc.contributor.author | Özbakkaloglu, B | |
| dc.date.accessioned | 2024-07-18T12:03:18Z | |
| dc.date.available | 2024-07-18T12:03:18Z | |
| dc.description.abstract | Aim: The emergence of multidrug-resistant tuberculosis (MDR-TB) is increasing, and the standard short-course regimen used for the treatment of TB is likely to be ineffective against MDR-TB, leading to the need for second-line drugs. In such situations, drug susceptibility testing is necessary to select an appropriate treatment regimen. Unfortunately, there are few studies showing the pattern of the second-line drug resistance in Turkey. We aimed to analyze the resistance to second-line anti-tuberculosis drugs of MDR strains of Mycobacterium tuberculosis isolated from the Aegean region of Turkey. Materials and Methods: In this study, drug susceptibility testing of 40 MDR-TB strains isolated from the Aegean region of Turkey was performed using the BACTEC 460 TB radiometric system. Capreomycin, ethionamide, kanamycin, amikacin, clofazimine and ofloxacin were tested in 1.25 mu g/ml, 1.25 mu g/ml, 5.0 mu g/ml, 1.0 mu g/ml, 0.5 mu g/ml, and 2.0 mu g/ml concentrations, respectively. Results: The results showed that 37.5% of the strains were resistant to ethionamide, 25% to capreomycin, 5% to kanamycin, amikacin and ofloxacin, and 2.5% to clofazimine. One (2.5%) of the 40 MDR-TB cases was defined as extensively drug-resistant tuberculosis (XDR-TB). Conclusions: The results of the study indicate that the high rates of resistance to ethionamide and capreomycin may be a problem in the treatment of patients with MDR-TB; XDR-TB is not yet a serious problem in our region. | |
| dc.identifier.issn | 1300-0144 | |
| dc.identifier.other | 1303-6165 | |
| dc.identifier.uri | http://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9031 | |
| dc.language.iso | English | |
| dc.publisher | Tubitak Scientific & Technological Research Council Turkey | |
| dc.subject | STRAINS | |
| dc.subject | RUSSIA | |
| dc.title | Second-line drug susceptibilities of multidirug-resistant Mycobacterium tuberculosis isolates in Aegean region - Turkey | |
| dc.type | Article; Proceedings Paper |