Reproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder

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dc.contributor.authorYorukoglu, K
dc.contributor.authorTuna, B
dc.contributor.authorDikicioglu, E
dc.contributor.authorDuzcan, E
dc.contributor.authorIsisag, A
dc.contributor.authorSen, S
dc.contributor.authorMungan, U
dc.contributor.authorKirkali, Z
dc.date.accessioned2024-07-18T12:06:17Z
dc.date.available2024-07-18T12:06:17Z
dc.description.abstractObjectives. This study assessed the diagnostic agreement and intra- and inter-observer reproducibility of the World Health Organization/International Society of Urologic Pathology Consensus Classification of Urothelial Neoplasms (1998 WHO/ISUP classification) and the 1973 WHO classification. Methods. A teaching set with 5 slides of each papillary neoplasm of low malignant potential, low-grade papillary carcinoma, high-grade papillary carcinoma, and a guideline, as well as a study set of 30 slides containing ten cases of each category, were sent to participants. Six pathologists expert in urological pathology reviewed the 30 slides of non-invasive papillary urothelial tumors in the study set. Diagnostic accuracy and reproducibility were evaluated using intra- and inter-rater techniques (kappa statistic). Results. A moderate to substantial intra- and inter-observer reproducibility was achieved for both the 1998 WHO/ISUP and 1973 WHO classification. The results of the two classification systems were not different statistically (P>0.05). Reproducibility was lower in low-grade tumors for both classifications. Conclusions. The new proposed classification system for non-invasive urothelial neoplasms does not increase the reproducibility. There is still a need for uniformity in grading in order to compare the different studies and therapies and to provide more accurate information for management.
dc.identifier.issn0945-6317
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10290
dc.language.isoEnglish
dc.publisherSPRINGER-VERLAG
dc.subjectTRANSITIONAL-CELL-CARCINOMA
dc.subject2-NUMBER GRADING SYSTEM
dc.subjectINTERNATIONAL-SOCIETY
dc.subjectINTEROBSERVER REPRODUCIBILITY
dc.subjectWHO/ISUP CLASSIFICATION
dc.subjectBIOLOGIC IMPLICATIONS
dc.subjectMITOTIC FREQUENCY
dc.subjectTUMORS
dc.subjectCANCER
dc.subjectORGANIZATION
dc.titleReproducibility of the 1998 World Health Organization/International Society of Urologic Pathology classification of papillary urothelial neoplasms of the urinary bladder
dc.typeArticle

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