99mTc(I) carbonyl-radiolabeled lipid based drug carriers for temozolomide delivery and bioevaluation by in vitro and in vivo

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dc.contributor.authorAri, K
dc.contributor.authorUçar, E
dc.contributor.authorIçhedef, Ç
dc.contributor.authorKilçar, AY
dc.contributor.authorMedine, EI
dc.contributor.authorParlak, Y
dc.contributor.authorBilgin, BES
dc.contributor.authorAydin, B
dc.contributor.authorGümüser, FG
dc.contributor.authorTeksöz, S
dc.date.accessioned2024-07-18T12:00:43Z
dc.date.available2024-07-18T12:00:43Z
dc.description.abstractIn preclinical research radiolabeled nanoparticles have been attracting interest as a new class of imaging probes. Assuming good stability of solid lipid nanoparticles (SLNs) under physiological conditions, radiolabeled SLNs can be used for imaging and measuring uptake in target tissue. Present study was performed to evaluate biological behavior of temozolomide (TMZ) loaded solid lipid nanoparticles (SLN-TMZ) in vivo and in vitro. Lipid nanoparticles were prepared by emulsification and low-temperature solidification method. zeta potential, morphology and particle size of nanoparticles were determined. Biological behavior of( 99m)Tc(CO)(3)(+) radiolabeled SLN-TMZ were investigated in vitro on U87/Daoy cell lines and in vivo on female Wistar Albino rats. Obtained results of in vitro incorporation, in vivo biodistribution and gamma imaging studies on radiolabeled SLN-TMZ show that the radiolabeled solid lipid nanoparticles could have potential as a drug delivery system for TMZ.
dc.identifier.issn0033-8230
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/7919
dc.language.isoEnglish
dc.publisherWALTER DE GRUYTER GMBH
dc.subjectNANOPARTICLES SLN
dc.subjectSTABILITY
dc.subjectAGENT
dc.title99mTc(I) carbonyl-radiolabeled lipid based drug carriers for temozolomide delivery and bioevaluation by in vitro and in vivo
dc.typeArticle

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