Oh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection

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dc.contributor.authorBoorom, KF
dc.contributor.authorSmith, H
dc.contributor.authorNimri, L
dc.contributor.authorViscogliosi, E
dc.contributor.authorSpanakos, G
dc.contributor.authorParkar, U
dc.contributor.authorLi, LH
dc.contributor.authorZhou, XN
dc.contributor.authorOk, ÜZ
dc.contributor.authorLeelayoova, S
dc.contributor.authorJones, MS
dc.date.accessioned2024-07-18T12:07:45Z
dc.date.available2024-07-18T12:07:45Z
dc.description.abstractBlastocystis is a prevalent enteric protozoan that infects a variety of vertebrates. Infection with Blastocystis in humans has been associated with abdominal pain, diarrhea, constipation, fatigue, skin rash, and other symptoms. Researchers using different methods and examining different patient groups have reported asymptomatic infection, acute symptomatic infection, and chronic symptomatic infection. The variation in accounts has lead to disagreements concerning the role of Blastocystis in human disease, and the importance of treating it. A better understanding of the number of species of Blastocystis that can infect humans, along with realization of the limitations of the existing clinical laboratory diagnostic techniques may account for much of the disagreement. The possibility that disagreement was caused by the emergence of particular pathogenic variants of Blastocystis is discussed, along with the potential role of Blastocystis infection in irritable bowel syndrome (IBS). Findings are discussed concerning the role of protease-activated receptor-2 in enteric disease which may account for the presence of abdominal pain and diffuse symptoms in Blastocystis infection, even in the absence of fever and endoscopic findings. The availability of better diagnostic techniques and treatments for Blastocystis infection may be of value in understanding chronic gastrointestinal illness of unknown etiology.
dc.identifier.issn1756-3305
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/10609
dc.language.isoEnglish
dc.publisherBMC
dc.subjectPROGRAMMED CELL-DEATH
dc.subjectIN-VITRO CULTIVATION
dc.subjectHOMINIS INFECTION
dc.subjectCLINICAL-SIGNIFICANCE
dc.subjectUNITED-STATES
dc.subjectMOLECULAR EPIDEMIOLOGY
dc.subjectENTAMOEBA-HISTOLYTICA
dc.subjectINTESTINAL PARASITES
dc.subjectULCERATIVE-COLITIS
dc.subjectCHRONIC URTICARIA
dc.titleOh my aching gut: irritable bowel syndrome, Blastocystis, and asymptomatic infection
dc.typeReview

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