Prevention of posterior capsule opacification by retinoic acid and mitomycin
| dc.contributor.author | Inan U.U. | |
| dc.contributor.author | Öztürk F. | |
| dc.contributor.author | Kaynak S. | |
| dc.contributor.author | Ilker S.S. | |
| dc.contributor.author | Özer E. | |
| dc.contributor.author | Güler C. | |
| dc.date.accessioned | 2025-04-10T11:18:19Z | |
| dc.date.available | 2025-04-10T11:18:19Z | |
| dc.date.issued | 2001 | |
| dc.description.abstract | Background: Our aim was to evaluate the effect of an intraoperative single dose of retinoic acid (RA) or mitomycin C (MMC) in preventing posterior capsule opacification (PCO). Methods: Twenty-seven rabbits were divided randomly into three groups. RA (250 μg/ml) and MMC (0.04 mg/ml) were given 0.1 ml by hydrosection and 0.9 ml into the capsular bag after phacoemulsification. The third group served as a control group. Three months after intervention PCO was graded clinically. Furthermore, proliferation of lens epithelial cells was evaluated histologically. Results: Two eyes developed corneal edema in the MMC group. On clinical assessment, RA and MMC were significantly effective in preventing PCO compared with controls (P<0.005). On histological analysis, there was significantly reduced proliferative activity on posterior capsules in the treatment groups, in contrast to multi-layer cells in the control group. Conclusion: Intraoperative single-dose administration of RA and MMC significantly prevented the development of PCO in rabbit eyes. The optimal biocompatible dosage must be carefully determined by further investigation. | |
| dc.identifier.DOI-ID | 10.1007/s004170100329 | |
| dc.identifier.uri | http://hdl.handle.net/20.500.14701/53378 | |
| dc.title | Prevention of posterior capsule opacification by retinoic acid and mitomycin | |
| dc.type | Article |