Expression profiles of histone modification genes in gastric cancer progression

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dc.contributor.authorOrenay-Boyacioglu, S
dc.contributor.authorKasap, E
dc.contributor.authorGerceker, E
dc.contributor.authorYuceyar, H
dc.contributor.authorDemirci, U
dc.contributor.authorBilgic, F
dc.contributor.authorKorkmaz, M
dc.date.accessioned2024-07-18T12:03:37Z
dc.date.available2024-07-18T12:03:37Z
dc.description.abstractGastric cancer (GC) development can be attributed to several risk factors including atrophic gastritis (AG), intestinal metaplasia (IM), and the presence of Helicobacter pylori (HP). Also, histone modification is an epigenetic mechanism that plays a pivotal role in GC carcinogenesis. In this preliminary study, we aimed to describe the expression profiles of histone modification in the AG, IM, and GC patient groups. A total of 80 patients with AG (n = 27), IM (n = 25), and GC (n = 28) with an additional 20 control subjects were included in the study. Expression profiles of three histone phosphorylation genes (PAK1, NEK6, and AURKA) and five histone deacetylation genes (HDACs 1, 2, 3, 5, and 7) were examined based on the results of Real Time qPCR method. It was observed that AURKA and HDAC2 genes were significantly overexpressed in all groups compared to the control (P < 0.05). In GC patients, overexpression of HDAC2 gene was detected in the absence of metastasis, and overexpression of AURKA, HDAC2, and NEK6 genes was detected in the presence of metastasis. When cancer involvements were compared, significant overexpression of the HDAC2 gene was noted in overall and corpus involvements (P < 0.05). In addition, overexpression of AURKA, NEK6, HDAC1, and HDAC2 genes and underexpression of HDAC5 gene were detected in the antrum involvement (P < 0.05). In conclusion, decreased expression of HDAC5 in GC is reported for the first time in this study, while supporting the existing literature in AURKA, NEK6, HDAC1, and HDAC2 up regulations during GC development.
dc.identifier.issn0301-4851
dc.identifier.other1573-4978
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/9256
dc.language.isoEnglish
dc.publisherSPRINGER
dc.subjectAURORA-KINASE
dc.subjectPROGNOSTIC MARKER
dc.subjectCELLS
dc.subjectOVEREXPRESSION
dc.subjectEPIDEMIOLOGY
dc.subjectCARCINOMA
dc.subjectNEK6
dc.subjectH3
dc.subjectH4
dc.titleExpression profiles of histone modification genes in gastric cancer progression
dc.typeArticle

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