Effect of recombinant human activated protein C on apoptosis-related proteins

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dc.contributor.authorSakar, A
dc.contributor.authorVatansever, S
dc.contributor.authorSepit, L
dc.contributor.authorOzbilgin, K
dc.contributor.authorYorgancioglu, A
dc.date.accessioned2024-07-18T11:49:34Z
dc.date.available2024-07-18T11:49:34Z
dc.description.abstractThe recombinant human activated protein C (rhAPC) has been reported to reduce mortality in patients with severe sepsis. An anti-apoptotic effect of rhAPC in sepsis is known, but the mechanism through which it acts on the apoptotic pathway is still unclear. Therefore, immunopositivity of the apoptosis-related proteins Bcl-2, an anti-apoptotic protein, c-myc, a proliferative protein, p-21 and p-53, two apoptotic proteins, was determined after rhAPC treatment in a mouse sepsis model. Sepsis was induced by Escherichia coli endotoxin injection. Increased neutrophil infiltration and immunoreactivity to p53 and p2l were observed in the group with sepsis and these immunoreactivities were decreased by rhAPC treatment. In the sepstic group; immunopositivity of Bcl-2 and c-myc was mild and moderate, respectively. In conclusion; p21- and p53-mediated apoptosis was increased in the sepsis model, and for the first time it has been shown that rhAPC decreases sepsis-induced apoptosis resulting from increased p2l and p53 proteins.
dc.identifier.issn1121-760X
dc.identifier.other2038-8306
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/4131
dc.language.isoEnglish
dc.publisherPAGEPRESS PUBL
dc.subjectPROGRAMMED CELL-DEATH
dc.subjectSEVERE SEPSIS
dc.subjectP53-MEDIATED APOPTOSIS
dc.subjectIMPROVES SURVIVAL
dc.subjectSEPTIC SHOCK
dc.subjectMYC ONCOGENE
dc.subjectBCL-2
dc.subjectEXPRESSION
dc.subjectMICE
dc.subjectREGULATORS
dc.titleEffect of recombinant human activated protein C on apoptosis-related proteins
dc.typeArticle

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