Comparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam

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dc.contributor.authorKeles, GT
dc.contributor.authorKurutepe, S
dc.contributor.authorTok, D
dc.contributor.authorGazi, H
dc.contributor.authorDinç, G
dc.date.accessioned2024-07-18T11:49:01Z
dc.date.available2024-07-18T11:49:01Z
dc.description.abstractBackground and objectives: The aim of our study was to investigate the antimicrobial effects of dexmedetomidine and etomidate-lipuro, and to compare these effects with those of midazolam and propofol on Staphylococcus aureus, Escherichia coli, Pseudomonas aeroginosa, Acinetobacter baumannii and extended-spectrum beta-lactamase Escherichia coli (E. coli ESBL). Methods: All hypnotic dilutions were exposed to micro-organisms for 0, 30, 60, 120 and 240 min at room temperature in vitro. The inoculums taken from diluted suspensions were re-inoculated on blood agar and incubated for 18-24 h at 35 degrees C after which a count of the colonies was compared. Results: Midazolam reduced the viable cells of S. aureus at 30, 60, 120 and 240 min, and also completely inhibited the growth of E. coli, R aeroginosa, A. baumannii and E. coli ESBL. Dexmedetomidine, etomidate-lipuro and propofol, however, did not inhibit any of the micro-organisms tested. Conclusion: In vitro, midazolam had an antimicrobial effect on E. coli, P aeroginosa, A. baumannii and E. coli ESBL. Like propofol and dexmedetomidine, etomidate-lipuro had no antimicrobial effect on any of the micro-organisms tested.
dc.identifier.issn0265-0215
dc.identifier.other1365-2346
dc.identifier.urihttp://akademikarsiv.cbu.edu.tr:4000/handle/123456789/3687
dc.language.isoEnglish
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.subjectSTAPHYLOCOCCUS-AUREUS
dc.subjectMICROBIAL-GROWTH
dc.subjectMICROORGANISMS
dc.subjectINFUSIONS
dc.subjectMIXTURES
dc.titleComparison of antimicrobial effects of dexmedetomidine and etomidate-lipuro with those of propofol and midazolam
dc.typeArticle

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